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Landsd\u00e6kkende database for patienter med kr\u00e6ft i bugspytkirtlen 2014-2015 [In Danish]. Cited 2015.12.17. Available from: <ext-link ext-link-type=\"uri\" xlink:href=\"http:\/\/www.dpcg.gicancer.dk\/\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\">http:\/\/www.dpcg.gicancer.dk\/<\/ext-link>."},{"key":"ref213","doi-asserted-by":"crossref","unstructured":"Burris HA, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, Cripps MC, Portenoy RK, Storniolo AM, Tarassoff P. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997;15:2403-2413.","DOI":"10.1200\/JCO.1997.15.6.2403"},{"key":"ref214","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011923"},{"key":"ref215","unstructured":"Liss AS, Thayer SP. Therapeutic targeting of pancreatic stroma. Source: Pancreatic Cancer and Tumor Microenvironment Trivandrum (India): Transworld Research Network; 2012;Chapter 9."},{"key":"ref216","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i9.2237"},{"key":"ref217","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181fd271c"},{"key":"ref218","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0371"},{"key":"ref219","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0b013e31829fb7a2"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v22\/i9\/2678.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T04:55:26Z","timestamp":1567659326000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v22\/i9\/2678.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":219,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.v22.i9.2678","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}