{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:35:46Z","timestamp":1778272546983,"version":"3.51.4"},"reference-count":126,"publisher":"Baishideng Publishing Group Inc.","issue":"36","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["WJG"],"published-print":{"date-parts":[[2018,9,28]]},"DOI":"10.3748\/wjg.v24.i36.4119","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T02:55:51Z","timestamp":1537844151000},"page":"4119-4131","source":"Crossref","is-referenced-by-count":48,"title":["Calcium-sensing receptor in colorectal inflammation and cancer: Current insights and future perspectives"],"prefix":"10.3748","volume":"24","author":[{"given":"Luca","family":"Iamartino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taha","family":"Elajnaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enik\u00f6","family":"Kallay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Schepelmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/366575a0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00563"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2012.12.011"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00248.2015"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa0282"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1113\/EP085137"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00341.2014"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00425.2011"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114513002250"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.10.040"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2013.05.010"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801738200"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.11.17"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.8963.1"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01511.x"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Heilbrun LK, Nomura A, Hankin JH, Stemmermann GN. Dietary vitamin D and calcium and risk of colorectal cancer. Lancet 1985; 925-925","DOI":"10.1016\/S0140-6736(85)91694-0"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2015.01.010"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.105205"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.04.027"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b03812"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.12.023"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7448"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1530\/EDM-17-0118"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/415719"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-016-0468-2"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2017.07.012"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.1.239"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12420"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28856"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.9.1390"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8648"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9799"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408587200"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.10.015"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708087200"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199202000-00014"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-014-0412-5"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1038\/nature11588"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3869561"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2011.11.002"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2012.03.006"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.05.007"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22198"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18010197"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1159\/000320276"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1210\/er.2008-0041"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.02.011"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.11.017"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-0360"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.281.6.E1267"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-0317"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-0687"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2006.02.009"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Lines C, Sanders JL, Chattopadhyay N, Kifor O, Yamaguchi T, Butters RR, Brown EM. Extracellular Calcium-Sensing Receptor Expression and Its Potential Role in Regulating Parathyroid Hormone-Related Peptide Secretion in Human Breast Cancer. 2015; 141: 0-7","DOI":"10.1210\/endo.141.12.7849"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2009.03.003"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2009.03.010"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16999"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-13-42"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-015-0330-4"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2017.01.017"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29681"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00119.2007"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19286-1"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.82.10.4300"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1002\/path.1489"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2007.03.014"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021427"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010-0277"},{"key":"ref69","doi-asserted-by":"crossref","unstructured":"Corbetta S, Mantovani G, Lania A, Borgato S, Vicentini L, Beretta E, Faglia G, Di Blasio AM, Spada A. Calcium-sensing receptor expression and signalling in human parathyroid adenomas and primary hyperplasia. Clin Endocrinol (Oxf) 2000; 52: 339-348","DOI":"10.1046\/j.1365-2265.2000.00933.x"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24304"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgs338"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.5.705"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-09-0012"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.10.7037"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1038\/nrc867"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-1082"},{"key":"ref77","doi-asserted-by":"crossref","unstructured":"Chattopadhyay N, Ye CP, Yamaguchi T, Kifor O, Vassilev PM, Nishimura R, Brown EM. Extracellular calcium-sensing receptor in rat oligodendrocytes: expression and potential role in regulation of cellular proliferation and an outward K+ channel. Glia 1998; 24: 449-458","DOI":"10.1002\/(SICI)1098-1136(199812)24:4<449::AID-GLIA10>3.0.CO;2-9"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21662"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00169"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61649-9"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i48.18151"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.01.058"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.12.036"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1038\/nri3430"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198511283132203"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1209"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgn229"},{"key":"ref88","doi-asserted-by":"crossref","unstructured":"Lipkin M. Preclinical and early human studies of calcium and colon cancer prevention. Ann N Y Acad Sci 1999; 889: 120-127","DOI":"10.1111\/j.1749-6632.1999.tb08729.x"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30293"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28840"},{"key":"ref91","unstructured":"Colorectal cancer. World Cancer Research Fund International. Available from: URL: https:\/\/www.wcrf.org\/int\/continuous-update-project\/cup-findings-reports\/colorectal-cancer"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-1560"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314163"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31021"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.07.001"},{"key":"ref96","doi-asserted-by":"crossref","unstructured":"Chakrabarty S, Wang H, Canaff L, Hendy GN, Appelman H, Varani J. Calcium sensing receptor in human colon carcinoma: interaction with Ca(2+) and 1,25-dihydroxyvitamin D(3). Cancer Res 2005; 65: 493-498","DOI":"10.1158\/0008-5472.493.65.2"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1177\/002215540004800503"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00500.2001"},{"key":"ref99","unstructured":"Chakrabarty S, Radjendirane V, Appelman H, Varani J. Extracellular calcium and calcium sensing receptor function in human colon carcinomas: promotion of E-cadherin expression and suppression of beta-catenin\/TCF activation. Cancer Res 2003; 63: 67-71"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6225"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1038\/nrg816"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.10"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.6.878"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28270"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1159\/000444493"},{"key":"ref106","doi-asserted-by":"crossref","unstructured":"Peters U, Chatterjee N, Yeager M, Chanock SJ, Schoen RE, McGlynn KA, Church TR, Weissfeld JL, Schatzkin A, Hayes RB. Association of genetic variants in the calcium-sensing receptor with risk of colorectal adenoma. Cancer Epidemiol Biomarkers Prev 2004; 13: 2181-2186","DOI":"10.1158\/1055-9965.2181.13.12"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.242"},{"key":"ref108","doi-asserted-by":"crossref","unstructured":"Mahmoudi T, Karimi K, Arkani M, Farahani H, Nobakht H, Dabiri R, Asadi A, Zali MR. Parathyroid hormone gene rs6256 and calcium sensing receptor gene rs1801725 variants are not associated with susceptibility to colorectal cancer in Iran. Asian Pac J Cancer Prev 2014; 15: 6035-6039","DOI":"10.7314\/APJCP.2014.15.15.6035"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0319"},{"key":"ref110","doi-asserted-by":"publisher","DOI":"10.1038\/ng1295-389"},{"key":"ref111","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17416"},{"key":"ref112","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2013.51"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0239"},{"key":"ref114","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-08-0157"},{"key":"ref115","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602852"},{"key":"ref116","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.274589"},{"key":"ref117","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00560.2007"},{"key":"ref118","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2011.00058"},{"key":"ref119","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201804200"},{"key":"ref120","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22123"},{"key":"ref121","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2015.02.006"},{"key":"ref122","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00451"},{"key":"ref123","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385952-5.00007-5"},{"key":"ref124","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12937"},{"key":"ref125","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.09.008"},{"key":"ref126","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001436"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v24\/i36\/4119.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T16:52:24Z","timestamp":1662137544000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1007-9327\/full\/v24\/i36\/4119.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,28]]},"references-count":126,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2018,9,28]]}},"URL":"https:\/\/doi.org\/10.3748\/wjg.v24.i36.4119","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9,28]]}}}