{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T07:28:24Z","timestamp":1774942104713,"version":"3.50.1"},"reference-count":62,"publisher":"Baishideng Publishing Group Inc.","issue":"46","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"DOI":"10.3748\/wjg.v28.i46.6573","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T05:07:17Z","timestamp":1670303237000},"page":"6573-6588","source":"Crossref","is-referenced-by-count":6,"title":["Safety and efficacy of purified clinoptilolite-tuff treatment in patients with irritable bowel syndrome with diarrhea: Randomized controlled trial"],"prefix":"10.3748","volume":"28","author":[{"given":"Karolina","family":"Anderle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Wolzt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Moser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Keip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Peter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Meisslitzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghazaleh","family":"Gouya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Freissmuth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelius","family":"Tschegg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.03.035"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.031"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18082"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2011.17.2.131"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.137.5.535"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S174982"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.04895.x"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1177\/102490790601300211"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04818.x"},{"key":"B10","unstructured":"Petkov V, Sch\u00fctz B, Eisenwagen S, Muss C, Mosgoeller W. PMA-zeolite can modulate inflammation associated markers in irritable bowel disease - an explorative randomized, double blinded, controlled pilot trial. Neuro Endocrinol Lett 2021; 42: 1-12"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02330.x"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3305\/nh.2015.32.2.8914"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24081517"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.4102\/safp.v59i1.4636"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.micromeso.2006.03.032"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S51222"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S81929"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1186\/s12970-015-0101-z"},{"key":"B19","unstructured":"Kloppers JR.   A andomized controlled trial of Absorbatox\u2122 C35 in Irritable Bowel Syndrome: A pilot study. Institutional Repository of the North-West University 2008"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.032"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.5382\/econgeo.4679"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsg.2020.104090"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12991"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-94245-x"},{"key":"B25","unstructured":"Glock G.   Inventor VALUE PRIVATSTIFTUNG, assignee. Method for removal of heavy metals. United States Patent US8173101B2; 2012"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3390\/cryst11111343"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23095143"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0252211"},{"key":"B29","unstructured":"EMA CfMPfHuC.   Guideline on the evaluation of medicinal products for the treatment of irritable bowel syndrome. CPMP\/EWP\/785\/97 Rev.1. [cited 25 September 2014]. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/guideline-evaluation-medicinal-products-treatment-irritable-bowel-syndrome-revision-1_en.pdf"},{"key":"B30","unstructured":"FDA.   Guidance for Industry Irritable Bowel Syndrome\u2014Clinical Evaluation of Drugs for Treatment, U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER). May 2012. Available from: https:\/\/www.fda.gov\/media\/78622\/download"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/s0895-4356(03)00027-1"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13746"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.142318000.x"},{"key":"B34","unstructured":"Morfeld M, Kirchberger I, Bullinger M.   SF-36 Fragebogen zum Gesundheitszustand: Deutsche Version des Short Form-36 Health Survey. 2., erg\u00e4nzte und \u00fcberarbeitete Auflage ed: Hogrefe-Verlag, 2011: 1-221"},{"key":"B35","unstructured":"Herrmann-Lingen C, Buss U, Snaith RP.   Hospital Anxiety and Depression Scale, Deutsche Version (HADS-D). [cited 25 October 2022]. Available from: https:\/\/www.testzentrale.de\/shop\/hospital-anxiety-and-depression-scale-deutsche-version-69320.html"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1026\/\/0012-1924.47.3.142"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.19"},{"key":"B38","unstructured":"Nutri-Science, GmbH.   Freiburger. Ern\u00e4hrungsprotokoll. [cited 25 October 2022]. Available from: https:\/\/www.ernaehrung.de\/static\/pdf\/freiburger-ernaehrungsprotokoll.pdf"},{"key":"B39","unstructured":"WHO.   Global Physical Activity Questionnaire (GPAQ) \u2013 Analysis Guide. [cited 25 October 2022]. Available from: https:\/\/www.who.int\/publications\/m\/item\/global-physical-activity-questionnaire"},{"key":"B40","unstructured":"Immundiagnostik AG.   IDK\u00aeIDO activity ELISA, 2021. [cited 25 October 2022]. Available from: https:\/\/www.immundiagnostik.com\/en\/testkits\/k-7726"},{"key":"B41","unstructured":"Immundiagnostik AG.   IDK\u00aeZonulin (Serum) ELISA, 2021. [cited 25 October 2022]. Available from: https:\/\/www.immundiagnostik.com\/en\/testkits\/k-5601"},{"key":"B42","unstructured":"Immundiagnostik AG.   IDK\u00aeBile Acids (Stool), photometric, 2021. [cited 25 October 2022]. Available from: https:\/\/www.immundiagnostik.com\/en\/testkits\/k-7878w"},{"key":"B43","unstructured":"Immundiagnostik AG.   \u03b2-Defensin 2 ELISA, 2021. [cited 25 October 2022]. Available from: https:\/\/www.immundiagnostik.com\/en\/testkits\/k-6500"},{"key":"B44","unstructured":"Immundiagnostik AG.   IDK\u00ae Gluten Fecal ELISA, 2021. [cited 25 October 2022]. Available from: https:\/\/www.immundiagnostik.com\/de\/testkits\/kt-5739"},{"key":"B45","unstructured":"Immundiagnostik AG.   IDK\u00ae Zonulin (Stuhl) ELISA, 2021. [cited 25 October 2022]. Available from: https:\/\/www.immundiagnostik.com\/de\/testkits\/k-5600"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.08.026"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001395"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3109\/00365529609006766"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1001\/archfami.8.3.243"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1007\/bf01296258"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1505180"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000327"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.15403\/jgld-4090"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30324-3"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3390\/nu9090940"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2019-101298"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15852"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-022-00777-x"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3390\/nu14132618"},{"key":"B60","doi-asserted-by":"crossref","unstructured":"Ford AC, Vandvik PO. Irritable bowel syndrome. BMJ Clin Evid 2012; 2012","DOI":"10.1053\/j.gastro.2012.10.006"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01136"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.18295\/squmj.2020.20.01.003"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v28\/i46\/6573.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v28\/i46\/6573.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T05:08:54Z","timestamp":1670303334000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v28\/i46\/6573.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,14]]},"references-count":62,"journal-issue":{"issue":"46"},"URL":"https:\/\/doi.org\/10.3748\/wjg.v28.i46.6573","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12,14]]}}}