{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T07:37:01Z","timestamp":1794555421594,"version":"4.9.1"},"reference-count":69,"publisher":"Baishideng Publishing Group Inc.","issue":"43","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Atractylodes japonica  Koidz. ex Kitam. (A. japonica , Chinese name: Guan-Cangzhu, Japanese name: Byaku-jutsu), a perennial herb, which is mainly distributed in northeast area of China, it\u2019s often used to treat digestive system diseases such as gastric ulcer (GU). However, the mechanism of its potential protective effects against GU remains unclear.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To investigate the protective effects of A. japonica  on acetic acid-induced GU rats.<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>The chemical constituents of A. japonica  were determined by ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS\/MS) analysis. The rat model of GU was simulated by acetic acid method. The pathological changes of gastric tissues were evaluated by hematoxylin-eosin stain, the levels of epidermal growth factor (EGF), EGF receptor (EGFR), nuclear factor kappa-B (NF-\u03baB), interleukin-1\u03b2 (IL-1\u03b2), IL-10, Na+-K+-ATPase (NKA) in serum and gastric tissues were determined by enzyme-linked immunosorbent assay, and the mRNA expressions of EGFR, NF-\u03baBp65, IkappaBalpha (I\u03baB\u03b1) and Zonula Occludens-1 (ZO-1) in gastric tissues were determined by real-time reverse transcription polymerase chain reaction, and the efficacy was observed. Then, plasma metabolomic analysis was performed by UPLC-MS\/MS to screen the specific potential biomarkers, metabolic pathways and to explore the possible mechanisms.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>48 chemical constituents were identified. Many of them have strong pharmacological activity, the results also revealed that A. japonica  significantly improved the pathological damage of gastric tissues, increased the expression levels of IL-10, I\u03baB\u03b1 related to anti-inflammatory factors, decreased the expression levels of IL-1\u03b2, NF-\u03baB, NF-\u03baBp65, related to proinflammatory factors, restored the levels of factors about EGF, EGFR, ZO-1 associated with ulcer healing and the levels of factors about NKA associated with energy metabolism. Metabolomic analysis identified 10 potential differential metabolites and enriched 7 related metabolic pathways.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>These findings contribute to the understanding of the potential mechanism of A. japonica  to improve acetic acid-induced GU, and will be of great importance for the development and clinical application of natural drugs related to A. japonica.<\/jats:p>","DOI":"10.3748\/wjg.v29.i43.5848","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T02:43:12Z","timestamp":1700448192000},"page":"5848-5864","source":"Crossref","is-referenced-by-count":14,"title":["Chemical components and protective effects of <i>Atractylodes japonica<\/i> Koidz. ex Kitam against acetic acid-induced gastric ulcer in rats"],"prefix":"10.3748","volume":"29","author":[{"given":"Bi-Xian","family":"Zhen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2023,11,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2169551"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2350-x"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2018.04.001"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.19540\/j.cnki.cjcmm.20180130.002"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2862706"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000392"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1560-3"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i45.17020"},{"key":"B9","unstructured":"Editorial board of Japan Pharmaceutical Administration.   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