{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T01:42:21Z","timestamp":1783906941545,"version":"3.55.0"},"reference-count":20,"publisher":"Baishideng Publishing Group Inc.","issue":"43","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Patients with autoimmune conditions receiving immunosuppressants are at risk of non-Hodgkin lymphomas (NHL). Vedolizumab (anti-\u03b14\u03b27-integrin antibody), a treatment-of-choice for Crohn\u2019s disease (CD), reduces inflammatory lymphocyte trafficking into the intestinal mucosa. This effect is believed to be confined to the colon.<\/jats:p>\n          <jats:p>CASE SUMMARY<\/jats:p>\n          <jats:p>We report the case of a CD patient on vedolizumab for five years who developed pediatric-type follicular lymphoma. Work-up prior to therapy revealed a reduction in circulating T-lymphocytes and their suppressed response to mitogens. Rituximab, cyclophosphamide, vincristine, and prednisone chemo-immunotherapy resulted in durable lymphoma remission, and vedolizumab treatment was continued. While the patient\u2019s T-lymphocyte population and immunoglobulin production recovered, the T-lymphocyte mitogen response remained suppressed.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>This patient\u2019s NHL may be linked to receiving anti-\u03b14\u03b27 therapy. Further research could be beneficial to determine if proactive surveillance for NHL and other systemic diseases is indicated in patients on vedolizumab.<\/jats:p>","DOI":"10.3748\/wjg.v29.i43.5865","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T02:43:12Z","timestamp":1700448192000},"page":"5865-5871","source":"Crossref","is-referenced-by-count":3,"title":["Pediatric-type follicular lymphoma in a Crohn\u2019s disease patient receiving anti-\u03b14\u03b27-integrin therapy: A case report"],"prefix":"10.3748","volume":"29","author":[{"given":"Keval","family":"Yerigeri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilia","family":"Buhtoiarov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2023,11,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.94"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-293050"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-12-682591"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.12.3671.bloodjournal85123671"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28416"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.01023.x"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.4.514"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2012.02588.x"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.651415"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.612830"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16060"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13247"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.56.1.1"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu290"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-04-842559"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-311079"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izac035"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-316023"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaa178"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.4049\/immunohorizons.2200009"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v29\/i43\/5865.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v29\/i43\/5865.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T02:43:45Z","timestamp":1700448225000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v29\/i43\/5865.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,21]]},"references-count":20,"journal-issue":{"issue":"43"},"URL":"https:\/\/doi.org\/10.3748\/wjg.v29.i43.5865","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11,21]]}}}