{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:10:59Z","timestamp":1791216659622,"version":"4.1.0"},"reference-count":30,"publisher":"Baishideng Publishing Group Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"BACKGROUND<\/jats:p>\n Eosinophilic gastroenteritis (EGE) is a chronic recurrent disease with abnormal eosinophilic infiltration in the gastrointestinal tract. Glucocorticoids remain the most common treatment method. However, disease relapse and glucocorticoid dependence remain notable problems. To date, few studies have illuminated the prognosis of EGE and risk factors for disease relapse.<\/jats:p>\n AIM<\/jats:p>\n To describe the clinical characteristics of EGE and possible predictive factors for disease relapse based on long-term follow-up.<\/jats:p>\n METHODS<\/jats:p>\n This was a retrospective cohort study of 55 patients diagnosed with EGE admitted to one medical center between 2013 and 2022. Clinical records were collected and analyzed. Kaplan-Meier curves and log-rank tests were conducted to reveal the risk factors for long-term relapse-free survival (RFS).<\/jats:p>\n RESULTS<\/jats:p>\n EGE showed a median onset age of 38 years and a slight female predominance (56.4%). The main clinical symptoms were abdominal pain (89.1%), diarrhea (61.8%), nausea (52.7%), distension (49.1%) and vomiting (47.3%). Forty-three (78.2%) patients received glucocorticoid treatment, and compared with patients without glucocorticoid treatments, they were more likely to have elevated serum immunoglobin E (IgE) (86.8% vs 50.0%, P = 0.022) and descending duodenal involvement (62.8% vs 27.3%, P = 0.046) at diagnosis. With a median follow-up of 67 mo, all patients survived, and 56.4% had at least one relapse. Six variables at baseline might have been associated with the overall RFS rate, including age at diagnosis < 40 years [hazard ratio (HR) 2.0408, 95% confidence interval (CI): 1.0082\u20134.1312, P = 0.044], body mass index (BMI) > 24 kg\/m2 (HR 0.3922, 95%CI: 0.1916-0.8027, P = 0.014), disease duration from symptom onset to diagnosis > 3.5 mo (HR 2.4725, 95%CI: 1.220-5.0110, P = 0.011), vomiting (HR 3.1259, 95%CI: 1.5246-6.4093, P = 0.001), total serum IgE > 300 KU\/L at diagnosis (HR 0.2773, 95%CI: 0.1204-0.6384, P = 0.022) and glucocorticoid treatment (HR 6.1434, 95%CI: 2.8446-13.2676, P = 0.003).<\/jats:p>\n CONCLUSION<\/jats:p>\n In patients with EGE, younger onset age, longer disease course, vomiting and glucocorticoid treatment were risk factors for disease relapse, whereas higher BMI and total IgE level at baseline were protective.<\/jats:p>","DOI":"10.3748\/wjg.v30.i2.146","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T10:14:25Z","timestamp":1704881665000},"page":"146-157","source":"Crossref","is-referenced-by-count":12,"title":["Long-term prognosis and its associated predictive factors in patients with eosinophilic gastroenteritis"],"prefix":"10.3748","volume":"30","author":[{"given":"Kai-Wen","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge-Chong","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Ming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Xun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Yu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Rong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Nan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2024,1,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197007000-00003"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.05.050"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000865"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2015.02.003"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.02958.x"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03122.x"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199805283382206"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.1.54"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.07.017"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000394"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.12.768"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.12.054"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.04.022"},{"key":"B14","unstructured":"Wong GW, Lim KH, Wan WK, Low SC, Kong SC. 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