{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:40:29Z","timestamp":1789000829675,"version":"build-2803163510"},"reference-count":24,"publisher":"Baishideng Publishing Group Inc.","issue":"27","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>The efficacy of Vonoprazan-amoxicillin dual therapy (VAT) in the treatment of Helicobacter pylori  (H. pylori ) is controversial.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To evaluate the efficacy of VAT in the Chinese population.<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>This prospective, multicenter, randomized, open-label, and two-stage study was conducted at 23 centers in Fujian, China (May 2021-April 2022). H. pylori -infected patients were randomized to bismuth quadruple therapy (BQT), BQT-Vonoprazan (BQT-V), seven-day VAT (VAT-7), ten-day VAT (VAT-10), and fourteen-day VAT (VAT-14) groups. The primary endpoint was the H. pylori  eradication rate. The secondary endpoint was the frequency of adverse events. This study was registered with the Chinese Clinical Trial Registry, ChiCTR2100045778.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>In the first stage, VAT-7 and BQT-V groups were selected for early termination because less than 23 among 28 cases were eradicated. In the second stage, the eradication rates for BQT, VAT-10, and VA-14 were 80.2% [95% confidence interval (95%CI): 71.4%-86.8%], 93.2% (86.6%-96.7%), 92.2% (85.3%-96.0%) in the intention-to-treat (ITT) analysis, and 80.9% (95%CI: 71.7%-87.5%), 94.0% (87.5%-97.2%), and 93.9% (87.4%-97.2%) in the per-protocol analysis. The ITT analysis showed a higher eradication rate in the VAT-10 and VAT-14 groups than in the BQT group (P  = 0.022 and P  = 0.046, respectively). The incidence of adverse events in the VAT-10 and VAT-14 groups was lower than in the BQT group (25.27% and 13.73% vs  37.62%, respectively; P  &lt; 0.001).<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>VAT with a duration of 10 or 14 days achieves a higher eradication rate than the BQT, with a more tolerable safety profile in H. pylori -infected patients in Fujian.<\/jats:p>","DOI":"10.3748\/wjg.v30.i27.3304","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T07:24:52Z","timestamp":1720682692000},"page":"3304-3313","source":"Crossref","is-referenced-by-count":19,"title":["Vonoprazan-amoxicillin dual therapy for <i>Helicobacter pylori<\/i> eradication in Chinese population: A prospective, multicenter, randomized, two-stage 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Phathom Pharmaceuticals Provides Update on New Drug Application Review of Vonoprazan for Erosive Esophagitis. [cited 20 June 2024]. 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