{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:55:36Z","timestamp":1792688136929,"version":"4.5.0"},"reference-count":73,"publisher":"Baishideng Publishing Group Inc.","issue":"30","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Fanlian Huazhuo Formula (FLHZF) has the functions of invigorating spleen and resolving phlegm, clearing heat and purging turbidity. It has been identified to have therapeutic effects on type 2 diabetes mellitus (T2DM) in clinical application. Non-alcoholic fatty liver disease (NAFLD) is frequently diagnosed in patients with T2DM. However, the therapeutic potential of FLHZF on NAFLD and the underlying mechanisms need further investigation.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To elucidate the effects of FLHZF on NAFLD and explore the underlying hepatoprotective mechanisms in vivo  and in vitro .<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>HepG2 cells were treated with free fatty acid for 24 hours to induce lipid accumulation cell model. Subsequently, experiments were conducted with the different concentrations of freeze-dried powder of FLHZF for 24 hours. C57BL\/6  mice were fed a high-fat diet for 8-week to establish a mouse model of NAFLD, and then treated with the different concentrations of FLHZF for 10 weeks.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>FLHZF had therapeutic potential against lipid accumulation and abnormal changes in biochemical indicators in vivo  and in vitro . Further experiments verified that FLHZF alleviated abnormal lipid metabolism might by reducing oxidative stress, regulating the AMPK\u03b1\/SREBP-1C signaling pathway, activating autophagy, and inhibiting hepatocyte apoptosis.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>FLHZF alleviates abnormal lipid metabolism in NAFLD models by regulating reactive oxygen species, autophagy, apoptosis, and lipid synthesis signaling pathways, indicating its potential for clinical application in NAFLD.<\/jats:p>","DOI":"10.3748\/wjg.v30.i30.3584","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T10:40:13Z","timestamp":1723113613000},"page":"3584-3608","source":"Crossref","is-referenced-by-count":13,"title":["Fanlian Huazhuo Formula alleviates high-fat diet-induced non-alcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling 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