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Later studies, however, showed a null effect of incretin-based therapy on CCA risk for dipeptidyl peptidase-4 inhibitor nor GLP-1R agonist. Mechanistically, glucagon-like peptide 1 receptor is multifunctional, including promoting cell growth. High GLP-1R expressions were associated with progressive phenotypes of CCA cells in vitro . Unexpectedly, the GLP-1R agonist showed anti-tumor effects on CCA cells in vitro  and in vivo  with unclear mechanisms. Our recent report also showed that GLP-1R agonists suppressed the expression of GLP-1R in CCA cells in vitro  and in vivo , leading to the inhibition of CCA tumor growth. This editorial reviews recent evidence, discusses the potential effects of GLP-1R agonists in CCA patients, and proposes underlying mechanisms that would benefit from further basic and clinical investigation.<\/jats:p>","DOI":"10.3748\/wjg.v30.i34.3862","type":"journal-article","created":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T15:38:08Z","timestamp":1725809888000},"page":"3862-3867","source":"Crossref","is-referenced-by-count":0,"title":["Glucagon-like peptide 1 receptor agonist: A potential game changer for cholangiocarcinoma"],"prefix":"10.3748","volume":"30","author":[{"given":"Ronnakrit","family":"Trakoonsenathong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Feng","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charupong","family":"Saengboonmee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2024,9,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0310-z"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00300-2"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2020-0032-RA"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.09.007"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01301-6"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-61282-1"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i39.7160"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-022-00536-8"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1530\/EC-21-0546"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.050464"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032428"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2018.9284"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118548"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i28.4416"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i9.948"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00155"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.2337\/dc24-S009"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1080\/07435800.2021.1955255"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i5340"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15382"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16091625"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.50408"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-02055-z"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-38956-2"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-023-05972-x"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k4880"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-021-05508-1"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-019-01444-0"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2022.0338"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.150870"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.04.007"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2019.10497"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-014-3302-7"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3390\/ijms141224293"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-64774-2"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v30\/i34\/3862.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v30\/i34\/3862.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T15:38:23Z","timestamp":1725809903000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v30\/i34\/3862.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,14]]},"references-count":35,"journal-issue":{"issue":"34"},"URL":"https:\/\/doi.org\/10.3748\/wjg.v30.i34.3862","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9,14]]}}}