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The pathogenesis of ALD is exceedingly complex. Previous studies have shown that peroxisome proliferator-activated receptors (PPARs) regulate lipid metabolism, glucose homeostasis and inflammatory responses within the organism. Additionally, their dysfunction is a major contributor to the progression of ALD. Elafibranor is an oral, dual PPAR\u03b1 and \u03b4 agonist. The effectiveness of elafibranor in the treatment of ALD remains unclear. In this letter, we emphasize the harm of ALD and the burden it places on society. Furthermore, we summarize the clinical management of all stages of ALD and present new insights into its pathogenesis and potential therapeutic targets. Additionally, we discuss the mechanisms of action of PPAR\u03b1 and \u03b4 agonists, the significance of their antifibrotic effects on ALD and future research directions.<\/jats:p>","DOI":"10.3748\/wjg.v30.i37.4163","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T05:56:42Z","timestamp":1727330202000},"page":"4163-4167","source":"Crossref","is-referenced-by-count":0,"title":["Dual peroxisome proliferator-activated receptor \u03b1\/\u03b4 agonists: Hope for the treatment of alcohol-associated liver disease?"],"prefix":"10.3748","volume":"30","author":[{"given":"Xin-Yang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin-Jun-Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v30.i28.3428"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.03.017"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-320446"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.06.018"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-023-01939-9"},{"key":"B6","unstructured":"World Health Organization.   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