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We summarize the impact and mechanisms of Elafibranor on ALD, metabolic-associated fatty liver disease, and cholestatic liver disease based on current research. We also explore its potential as a dual agonist of PPAR\u03b1\/\u03b4, which is undergoing Phase III clinical trials for metabolic-associated steatohepatitis. Our goal is to stimulate further investigation into Elafibranor's use for preventing and treating these liver diseases and to provide insights for its clinical application.<\/jats:p>","DOI":"10.3748\/wjg.v30.i40.4393","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T01:47:18Z","timestamp":1729043238000},"page":"4393-4398","source":"Crossref","is-referenced-by-count":11,"title":["Elafibranor: A promising treatment for alcoholic liver disease, metabolic-associated fatty liver disease, and cholestatic liver disease"],"prefix":"10.3748","volume":"30","author":[{"given":"Hang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Shan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.969979"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/foods12132469"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-024-02959-2"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1195146"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.03.017"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009241"},{"key":"B7","unstructured":"Wu JH, OuYang LQ, Ou YT, Deng GM. 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