{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:20:55Z","timestamp":1792725655646,"version":"4.5.0"},"reference-count":42,"publisher":"Baishideng Publishing Group Inc.","issue":"43","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"<jats:p>The gut-liver axis plays a crucial role in the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). Key metabolites, including lipopolysaccharides, short-chain fatty acids (SCFAs), bile acids, and beneficial gut bacteria such as Bifidobacterium and Lactobacillus, are pivotal in this process. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) show promise in managing MASLD by promoting weight loss, enhancing insulin secretion, and improving liver health. They restore gut-liver axis functionality, and their effects are amplified through dietary modifications and gut microbiome-targeted therapies. Emerging research highlights the interplay between GLP-1 RAs and gut microbiota, indicating that the gut microbiome significantly influences therapeutic outcomes. Metabolites produced by gut bacteria, can stimulate glucagon-like peptide-1 (GLP-1) secretion, further improving metabolic health. Integrating dietary interventions with GLP-1 RA treatment may enhance liver health by modulating the gut microbiota-SCFAs-GLP-1 pathway. Future research is needed to understand personalized effects, with prebiotics and probiotics offering treatment avenues for MASLD.<\/jats:p>","DOI":"10.3748\/wjg.v30.i43.4682","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T03:23:36Z","timestamp":1730345016000},"page":"4682-4688","source":"Crossref","is-referenced-by-count":27,"title":["Interplay of gut microbiota, glucagon-like peptide receptor agonists, and nutrition: New frontiers in metabolic dysfunction-associated steatotic liver disease therapy"],"prefix":"10.3748","volume":"30","author":[{"given":"Merve","family":"Guney-Coskun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metin","family":"Basaranoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2024,11,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30251"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.11.312"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2023.2225667"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i8.1166"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i18.2223"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2024.155835"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v30.i23.2964"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00082"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-52103-x"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-010-0093-z"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.21037\/hbsn.2020.03.27"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-021-05188-7"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000349"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0269-9"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10020270"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101351"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/apt.17848"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21006"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00476.2011"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23569"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02462.x"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11020073"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2023.102849"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2017-000554"},{"key":"B25","unstructured":"New joint statement regarding GLP-1\/GIP Receptor Agonists for people living with obesity and\/or type 2 diabetes released. British Dietetic Association. 2024. Available from: https:\/\/www.bda.uk.com\/resource\/new-joint-statement-regarding-glp-1-gip-receptor-agonists-for-people-living-with-obesity-and-or-type-2-diabetes-released.html"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00233"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-020-01657-8"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.17891"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1048693"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.02032-23"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.06.020"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00472-y"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1509"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.03.032"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665118002756"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01673-4"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.906511"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuad086"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/s41387-024-00281-7"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3390\/metabo14070366"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.06.013"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10030550"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v30\/i43\/4682.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v30\/i43\/4682.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T03:25:48Z","timestamp":1730345148000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v30\/i43\/4682.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,21]]},"references-count":42,"journal-issue":{"issue":"43"},"URL":"https:\/\/doi.org\/10.3748\/wjg.v30.i43.4682","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11,21]]}}}