{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T06:31:44Z","timestamp":1762929104372,"version":"3.28.0"},"reference-count":32,"publisher":"Baishideng Publishing Group Inc.","issue":"44","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant and aggressive tumor, and high Ki-67 expression indicates poor histological differentiation and prognosis. Therefore, one of the challenges in diagnosing preoperatively patients with PDAC is predicting the degree of malignancy. Dynamic contrast-enhanced ultrasonography (DCE-US) plays a crucial role in abdominal tumor diagnosis, and can adequately show the microvascular composition within the tumors. However, the relationship between DCE-US and the Ki-67 labelling index remains unclear at the present time.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To predict the correlation between Ki-67 expression and the parameters of DCE-US.<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>Patients with PDAC who underwent DCE-US were retrospectively analyzed. Patients who had received any treatment (radiotherapy or chemotherapy) prior to DCE-US; had incomplete clinical, imaging, or pathologic information; and had poor-quality image analysis were excluded. Correlations between Ki-67 expression and the parameters of DCE-US in patients with PDAC were assessed using Spearman\u2019s rank correlation analysis. The diagnostic performances of these parameters in high Ki-67 expression group were evaluated according to receiver operating characteristic curve.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>Based on the Ki-67 labelling index, 30 patients were divided into two groups, i.e. , the high expression group and the low expression group. Among the relative quantitative parameters between the two groups, relative half-decrease time (rHDT), relative peak enhancement, relative wash-in perfusion index and relative wash-in rate were significantly different between two groups (P  = 0.018, P  = 0.025, P  = 0.028, P  = 0.035, respectively). The DCE-US parameter rHDT was moderately correlated with Ki-67 expression, and rHDT \u2265 1.07 was more helpful in accurately diagnosing high Ki-67 expression, exhibiting a sensitivity and specificity of 53.8% and 94.1%, respectively.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>One parameter of DCE-US, rHDT, correlates with high Ki-67 expression. It demonstrates that parameters obtained noninvasively by DCE-US could better predict Ki-67 expression in PDAC preoperatively.<\/jats:p>","DOI":"10.3748\/wjg.v30.i44.4697","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T03:07:26Z","timestamp":1731294446000},"page":"4697-4708","source":"Crossref","is-referenced-by-count":2,"title":["Correlation of dynamic contrast-enhanced ultrasonography and the Ki-67 labelling index in pancreatic ductal adenocarcinoma"],"prefix":"10.3748","volume":"30","author":[{"given":"Xiao-Jing","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Xian","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Yun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Chang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21626"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2020.01.011"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9207616"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/bjs5.50175"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1177\/10732748241272463"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1055\/a-0586-1107"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-011-2373-2"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10091870"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3233\/CH-190786"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3233\/CH-201085"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2021.11.005"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-023-10393-w"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0000000000000274"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14486"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2023.0363"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.14016"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.823505"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i2.628"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.07.007"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-48445-2"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-022-09168-6"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2013.04.016"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12112662"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.23622"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1186\/s13244-024-01617-8"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13020238"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13203270"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03444-3"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-013-1409-1"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15890"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12159"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v30\/i44\/4697.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v30\/i44\/4697.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T03:07:32Z","timestamp":1731294452000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v30\/i44\/4697.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,28]]},"references-count":32,"journal-issue":{"issue":"44"},"URL":"https:\/\/doi.org\/10.3748\/wjg.v30.i44.4697","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11,28]]}}}