{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T05:20:13Z","timestamp":1732080013161,"version":"3.28.0"},"reference-count":32,"publisher":"Baishideng Publishing Group Inc.","issue":"46","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"<jats:p>The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) has increased significantly in recent decades and is projected to increase further due to the rising obesity rates. MASLD patients are at higher risk of developing advanced liver diseases \u201ccirrhosis and hepatocellular carcinoma\u201d as well as liver- or cardiovascular-related mortality. Existing lipid-lowering therapies failed to reduce the risk of mortality in these patients. Therefore, there is an urgent need for pharmacotherapies that can control and even reverse this disease. Fanlian Huazhuo Formula (FLHZF) is a combination herbal preparation, and its various individual constituents regulate hepatic lipid metabolism, adipose tissue inflammation, and gut microbiota. Despite, these useful effects, limited information is available on its benefits in diet-induced hepatosteatosis. In this article, we discuss the research findings recently published about the therapeutic effects of FLHZF in suppressing MASLD development and underlying mechanisms. Utilizing a series of in vitro  and in vivo  experiments, the authors demonstrated for the first time that FLHZF suppresses MASLD in male mice possibly by inhibiting hepatic de novo  lipogenesis pathways and reducing hepatocyte death. This study paves the way for future investigations aimed at investigating FLHZF\u2019s role in inhibiting lipogenesis particularly using radioactively-labeled glucose and acetate, and governing hepatocyte mitochondrial function, gut microbiome profile, and its effects in other models of MASLD, and female mice.<\/jats:p>","DOI":"10.3748\/wjg.v30.i46.4964","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T08:53:43Z","timestamp":1732006423000},"page":"4964-4968","source":"Crossref","is-referenced-by-count":0,"title":["Fanlian Huazhuo Formula: A promising herbal preparation for metabolic liver disease"],"prefix":"10.3748","volume":"30","author":[{"given":"Bhupesh","family":"Singla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2024,12,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v30.i30.3584"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.03.006"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00381-6"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00759-2"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.18-3-245"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10110912"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2024.02.007"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15738"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.10.051"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309000"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02603-1"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad072"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.17925\/EE.2023.19.1.60"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.015"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28985"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1172\/JCI77812"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(14)70032-4"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24341"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100255108"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0104-9"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800079-JLR200"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41636"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405238101"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115338"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.108363"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M071522"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2015.04.017"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqaa134"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3390\/nu9101072"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3390\/nu15010040"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.31.8.1035"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v30\/i46\/4964.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v30\/i46\/4964.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T08:54:24Z","timestamp":1732006464000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v30\/i46\/4964.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,14]]},"references-count":32,"journal-issue":{"issue":"46"},"URL":"https:\/\/doi.org\/10.3748\/wjg.v30.i46.4964","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12,14]]}}}