{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:27:59Z","timestamp":1792301279563,"version":"4.4.0"},"reference-count":16,"publisher":"Baishideng Publishing Group Inc.","issue":"48","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"BACKGROUND<\/jats:p>\n For the treatment of gastritis, rebamipide, a mucoprotective agent, and nizatidine, a gastric acid suppressant, are commonly employed individually.<\/jats:p>\n AIM<\/jats:p>\n To compare the efficacy of Mucotra\u00ae SR (rebamipide 150 mg) and Axid\u00ae (nizatidine 150 mg) combination therapy with the sole administration of Axid\u00ae in managing erosive gastritis.<\/jats:p>\n METHODS<\/jats:p>\n A total of 260 patients diagnosed with endoscopically confirmed erosive gastritis were enrolled in this open-label, multicenter, randomized, phase 4 clinical trial, allocating them into two groups: Rebamipide\/nizatidine combination twice daily vs nizatidine twice daily for 2 weeks. The full-analysis set analysis encompassed 239 patients (rebamipide\/nizatidine, n = 121; nizatidine, n = 118), while the per-protocol analysis included 218 patients (n = 110 vs 108). Post-treatment assessments comprised primary (erosion improvement rate) and secondary (erosion and edema cure rates, erythema improvement rates, hemorrhage, and gastrointestinal symptoms) endpoints. Furthermore, drug-related adverse effects were evaluated.<\/jats:p>\n RESULTS<\/jats:p>\n Primary efficacy assessment showed a statistically significant improvement rate in mucosal erosions in the combination group compared to the control group in the full-analysis set (rebamipide\/nizatidine 62.0%, nizatidine 49.2%, P = 0.046), with a similar trend noted in the per-protocol analysis (62.7% vs 50.0%, P = 0.058). Both groups were effective in curing erosion and edema and improvement of bleeding, erythema, and gastrointestinal symptoms, whereas no inter-group differences were noted. When confined to the participants with gastritis symptoms, improvement of erosion was more optimal in the combination group (63.0% vs 49.5%, P = 0.046). No adverse events related to the drugs were observed.<\/jats:p>\n CONCLUSION<\/jats:p>\n Rebamipide\/nizatidine combination is effective in treatment of erosive gastritis.<\/jats:p>","DOI":"10.3748\/wjg.v30.i48.5152","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T02:25:33Z","timestamp":1732847133000},"page":"5152-5161","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and safety of rebamipide\/nizatidine in patients with erosive gastritis: A randomized, multicenter, phase 4 study"],"prefix":"10.3748","volume":"30","author":[{"given":"Donghoon","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung-Gyu","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Nam","family":"Shim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Kyung","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Joo","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Ho","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Gyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam-Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Jin","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Joo","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Il","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang Lak","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Yup","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Oh","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Min","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Moon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Hwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang Eon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Seop","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Dong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Sik","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Jun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2024,12,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5107(95)70043-9"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.7704\/kjhugr.2012.12.4.237"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v5.i3.90"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2007.08.002"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3109\/00365529409091413"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3109\/00365528709094480"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000020620"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.5009\/gnl20338"},{"key":"B9","unstructured":"Arakawa T, Kobayashi K, Yoshikawa T, Tarnawski A. Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing. Dig Dis Sci 1998; 5S-13S"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001538"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-11505-0"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v10.i16.2379"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2017.32.11.1807"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2017.370"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.7704\/kjhugr.2013.13.3.173"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-017-4871-9"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v30\/i48\/5152.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v30\/i48\/5152.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T02:25:46Z","timestamp":1732847146000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v30\/i48\/5152.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,28]]},"references-count":16,"journal-issue":{"issue":"48"},"URL":"https:\/\/doi.org\/10.3748\/wjg.v30.i48.5152","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12,28]]}}}