{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T02:40:08Z","timestamp":1742956808822,"version":"3.40.3"},"reference-count":36,"publisher":"Baishideng Publishing Group Inc.","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Occult pancreaticobiliary reflux (OPBR) is characterized by the absence of congenital anomalies at the pancreaticobiliary junction yet leads to altered bile composition and an increased incidence of gallbladder stones.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To explore the computed tomography (CT) imaging characteristics of gallbladder stones in patients diagnosed with OPBR.<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>We analyzed 362 patients undergoing cholecystectomy (November 2020 to January 2022). Intraoperative bile samples were assayed for amylase (&gt; 110 U\/L indicated OPBR). CT features, including stone density and visibility, were compared between 54 OPBR and 308 controls. Stone attenuation (HU) was measured under standardized conditions (uCT-780, 120 kVp, 160 mAs). Logistic regression and receiver operating characteristic curve analysis identified independent OPBR predictors, forming a validated nomogram.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>OPBR patients exhibited significantly higher rates of CT-invisible stones (35.2% vs  12.3%) and uniform stones (87% vs  73.1%) along with lower overall stone density (P  = 0.01). Logistic regression identified stone visibility, uniformity, and density as independent predictors. A nomogram integrating these features with patient age achieved high diagnostic accuracy (area under the curve = 0.71).<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>CT imaging distinctly identifies gallbladder stone density, indicating a heightened risk of OPBR in patients with uniform and CT-invisible stones. Such imaging is crucial for preoperative assessments to evaluate potential recurrent biliary pathologies post-cholecystectomy.<\/jats:p>","DOI":"10.3748\/wjg.v31.i12.100855","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T02:06:34Z","timestamp":1742954794000},"source":"Crossref","is-referenced-by-count":0,"title":["Characterization of gallbladder stones associated with occult pancreaticobiliary reflux using computed 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