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Questions still remain, such as: Is the observed downregulation of PLD2 a causal factor or an epiphenomenon? Does PLD2 modulation offer a tangible therapeutic benefit beyond a mere correlation? These questions highlight the necessity of mechanistic in vivo  studies to validate the role and therapeutic potential of PLD2. Furthermore, interindividual variability in inflammatory responses raises concerns regarding PLD2\u2019s predictive consistency across genetically diverse populations. The temporal dynamics of PLD2 expression in AP also remain unclear; establishing whether its variations precede clinical deterioration is essential for its use in early risk stratification, integrating multiomics research (proteomics, metabolomics, transcriptomics, and lipidomics), which can clarify the biological interactions and regulatory pathways of PLD2 under complex mechanisms. Likewise, well-designed, multicenter, prospective studies will be essential in determining its true clinical value. The research by Wang et al  initiates an intriguing direction in the quest for AP biomarkers, but further research is required before PLD2 can be established as a clinically applicable tool. Additional efforts are required to close this gap and define whether its role transcends a mere association in order for it to become a therapeutic target.<\/jats:p>","DOI":"10.3748\/wjg.v31.i28.108271","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T01:00:28Z","timestamp":1753318828000},"source":"Crossref","is-referenced-by-count":0,"title":["Phospholipase D2: A biomarker implicated in various pancreatic diseases beyond acute pancreatitis"],"prefix":"10.3748","volume":"31","author":[{"given":"Ana I","family":"Tornel Avelar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Navarro","family":"Gerrard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan Adrian","family":"Priego Parra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v31.i11.104033"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000001757"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v31.i2.97239"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.123166"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200102000-00009"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199802000-00011"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2022.01.003"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/cas.16393"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-020-00294-3"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.391"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-024-02988-y"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-025-02226-2"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0527-2"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-018-0429-1"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2022.100924"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2017.11.004"},{"key":"B17","unstructured":"Guleken Z, Ozbeyli D, Acikel-Elmas M, Oktay S, Alev B, Sirvanci S, Velioglu Ogunc A, Kasimay Cakir O. 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