{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:15:02Z","timestamp":1783606502735,"version":"3.55.0"},"reference-count":115,"publisher":"Baishideng Publishing Group Inc.","issue":"42","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"<jats:p>Inflammatory bowel disease (IBD), a chronic disorder characterized by intestinal inflammation and mucosal damage, includes mainly Crohn\u2019s disease and ulcerative colitis. However, the cause of its onset remains unclear. The pathogenesis of IBD is closely related to host genetic susceptibility, disorders of the intestinal flora, damage to the intestinal mucosal barrier, and abnormal intestinal mucosal immunity. On the basis of the progress in research on the structure of the intestinal microbiota involved in IBD, the influence of genetics on the intestinal barrier and intestinal microbiota; the metagenomics, metatranscriptomics, and metabolomics of the intestinal microbiota involved in IBD; and treatments such as probiotics and fecal microbiota transplantation are important for the future treatment of IBD and the development of drugs for effective treatment.<\/jats:p>","DOI":"10.3748\/wjg.v31.i42.113170","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T01:06:21Z","timestamp":1762995981000},"source":"Crossref","is-referenced-by-count":2,"title":["Research progress concerning the involvement of the intestinal microbiota in the occurrence and development of inflammatory bowel disease"],"prefix":"10.3748","volume":"31","author":[{"given":"Lie","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Lei","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v31.i18.105472"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i5.502"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2023.2278424"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v31.i6.101266"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v11.i21.4975"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v10.i30.10823"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v31.i7.96459"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.24272\/j.issn.2095-8137.2024.409"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-11-61"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00405-20"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00387"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1177\/17562848241230896"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309333"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195310"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI62236"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.04.022"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1084\/jem.2001889"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2020.02.018"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.09.009"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/ni0802-715"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aao4755"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.058"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000775"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa9420"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad9948"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.07.001"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.114"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz046"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06946-z"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12807"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2012-13-9-r79"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16458"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.9848"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0213-6"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-017-0490-5"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1186\/s13099-019-0341-6"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314352"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/nature25172"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804812105"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307649"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06125-0"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.01.005"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202412234"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2014.919018"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-018-1723-0"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/nature10209"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/nature11582"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-030409-101225"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/nature22969"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1126\/science.1135245"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312135"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.05.047"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4102"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008018"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.015"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-021-00598-5"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v10.i32.11671"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-025-04395-7"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v31.i5.99913"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1515\/med-2021-0270"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2025.112814"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3390\/nu16183108"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3390\/jpm15030094"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11010013"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2024.04.005"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.5230\/jgc.2024.24.e4"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14010019"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24093"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.960693"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.5662\/wjm.v15.i2.92592"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222011243"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2154092"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-48175-5"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317516"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1247151"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.4103\/RPS.RPS_273_23"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.semerg.2025.102575"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106530"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3390\/ph17030347"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3390\/nu15204466"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.3390\/nu15102275"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2023.127550"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaf093"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202000461"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2025.128280"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02175-2"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.3390\/nu14153212"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.3390\/nu14132664"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.3390\/nu13093143"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118968"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.13131"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i14.2078"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12636"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.7150\/thno.103983"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1177\/20406223231182367"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.733992"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-71939-2"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1039\/d5ra03731j"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2025.2471737"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i20.3185"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-68619-w"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.21037\/tgh-24-138"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.17235\/reed.2022.8814\/2022"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12938"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab165"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14155260"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10184055"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313235"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-308896"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.01.007"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjw051"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.04.010"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309398"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309184"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318719"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v31\/i42\/113170.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v31\/i42\/113170.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T01:06:47Z","timestamp":1762996007000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v31\/i42\/113170.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,14]]},"references-count":115,"journal-issue":{"issue":"42"},"alternative-id":["113170"],"URL":"https:\/\/doi.org\/10.3748\/wjg.v31.i42.113170","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,14]]}}}