{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T22:16:03Z","timestamp":1773440163072,"version":"3.50.1"},"reference-count":34,"publisher":"Baishideng Publishing Group Inc.","issue":"43","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>The feasibility and safety of radiofrequency ablation (RFA) for oligometastatic colorectal liver metastases (CRLM) have been well established. However, the role of RFA in multiple metastases after first-line chemotherapy failure remains underexplored.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To assess long-term survival and factors affecting outcomes of RFA in patients with multiple refractory CRLM.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>A retrospective study was conducted on patients who underwent ablation of CRLM at our institution between January 2015 and June 2024. A total of 80 patients were included, with 42 individuals receiving single-session ablation and 38 underwent repeat ablation. Enhanced computed tomography imaging was utilized to evaluate procedural efficacy 24 hours post-RFA, followed by follow-up scans every 3-4 months. Progression-free survival (PFS) and overall survival (OS) rates were compared at endpoint using Kaplan-Meier curves. Cox regression was used to identify the factors associated with OS and PFS.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>The technical success rate was recorded at 98.7%. At endpoint, 42 (52.5%) patients achieved tumor-free survival, while 28 (35%) remained alive with residual tumors present. No significant OS\/PFS differences existed between single-session (median follow-up 29.5 months, median PFS 24.5 months) and repeat ablation (30 months, 14 months) cohorts (P  &gt; 0.05). Multivariate analysis showed that larger tumor size (P  &lt; 0.001) and older age (P  = 0.01) were associated with worse OS. The median PFS was 13.5 months, with tumor size emerging as the only independent predictor (P  = 0.04).<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>For patients with multiple refractory CRLM, both single-session ablation and repeat ablation can increase the proportion of patients achieving tumor-free status. However, careful consideration is necessary for ablation of metastases larger than 2.7 cm.<\/jats:p>","DOI":"10.3748\/wjg.v31.i43.111494","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T10:02:07Z","timestamp":1763546527000},"source":"Crossref","is-referenced-by-count":1,"title":["Repeat ablation and single-session ablation in patients with multiple colorectal cancer liver metastases after chemotherapy failure"],"prefix":"10.3748","volume":"31","author":[{"given":"Si-Qi","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi-Yu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian-An","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.0106"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-019-02182-z"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djx015"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4716-8"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2019.12.003"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3925-x"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7032"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.186379"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2017.10.209"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02505"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2018-0337"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.4450"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-020-00967-y"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10447"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1177\/000313481808401237"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12111851"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15174346"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-015-3779-z"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2002.02081.x"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2011.01.451"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2019.07.016"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2018.12.010"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu580"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00122-9"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00839"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6889"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.gcb.2008.01.034"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015142489"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-008-1258-5"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-016-1413-3"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-017-0452-6"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14030693"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21504"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v31\/i43\/111494.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v31\/i43\/111494.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T10:02:14Z","timestamp":1763546534000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v31\/i43\/111494.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,21]]},"references-count":34,"journal-issue":{"issue":"43"},"alternative-id":["111494"],"URL":"https:\/\/doi.org\/10.3748\/wjg.v31.i43.111494","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,21]]}}}