{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T21:40:26Z","timestamp":1788903626468,"version":"build-2803163510"},"reference-count":31,"publisher":"Baishideng Publishing Group Inc.","issue":"44","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Amphicrine carcinoma is an extremely rare entity. In this article, we report the first known case of very-early-stage amphicrine carcinoma characterized by a mixed growth pattern with multiple pathological components.<\/jats:p>\n                  <jats:p>CASE SUMMARY<\/jats:p>\n                  <jats:p>A 59-year-old male patient underwent gastroscopy for abdominal discomfort, which revealed a 1.5 cm elevated lesion on the lower part of the anterior aspect of the gastric body close to the gastric angle. Initial biopsy indicated signet-ring cell carcinoma (SRCC) confined to the mucosa. Following endoscopic submucosal dissection, pathological examination revealed signet-ring cells arranged in both nested clusters and diffuse infiltration demonstrating immunohistochemical positivity for periodic acid-Schiff staining for mucin, chromogranin A, and synaptophysin. The coexistence of these endocrine and exocrine markers supported the diagnosis of amphicrine carcinoma. A mixed growth pattern comprising poorly differentiated adenocarcinoma, neuroendocrine tumor, and SRCC was identified. Whether the amphicrine carcinoma arose directly from multipotent stem cells or differentiation from signet-ring cells remains unclear.<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>Routine neuroendocrine immunohistochemical marker staining for SRCC may improve the diagnosis of amphicrine carcinoma and provide guidance for subsequent treatment.<\/jats:p>","DOI":"10.3748\/wjg.v31.i44.112187","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T09:20:43Z","timestamp":1764235243000},"source":"Crossref","is-referenced-by-count":1,"title":["Very-early-stage gastric amphicrine carcinoma with mixed histology: A case report and review of literature"],"prefix":"10.3748","volume":"31","author":[{"given":"Cai-Zhi","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Zhu","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.11.016"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1177\/10668969251333111"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.59205"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.5858\/2001-125-1513-AGC"},{"key":"B5","unstructured":"Bo\u015foteanu M, Bo\u015foteanu C, Deacu M, A\u015fchie M. 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