{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:19:54Z","timestamp":1788265194441,"version":"build-2803163510"},"reference-count":16,"publisher":"Baishideng Publishing Group Inc.","issue":"44","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"BACKGROUND<\/jats:p>\n Chronic hepatitis B (CHB) patients rarely achieve functional cure with initial pegylated interferon alpha-2b (Peg-IFN\u03b1-2b) therapy. Validated tools to guide retreatment candidates are lacking. We hypothesized that clinical indicators predict hepatitis B surface antigen (HBsAg) clearance during retreatment.<\/jats:p>\n AIM<\/jats:p>\n To develop a prediction model for HBsAg clearance in Peg-IFN\u03b1-2b retreatment.<\/jats:p>\n METHODS<\/jats:p>\n In this retrospective cohort study, we enrolled 135 CHB\/compensated cirrhosis patients receiving Peg-IFN\u03b1-2b retreatment after initial non-clearance at Tianjin University Central Hospital (2017-2025). Predictors were identified through univariate Cox, least absolute shrinkage and selection operator, and multivariate Cox regression. Model performance was assessed via receiver operating characteristic analysis and Harrell\u2019s C-index, with risk stratification by X-tile optimization.<\/jats:p>\n RESULTS<\/jats:p>\n HBsAg clearance rate was 20.74% (28\/135). Independent predictors included: Combination nucleos(t)ide analogue (NA) therapy during initial treatment [hazard ratio (HR) = 0.276, 95% confidence interval (CI): 0.092-0.833], baseline HBsAg at retreatment (HR = 0.571, 95%CI: 0.410-0.795), HBsAg decline after initial treatment (HR = 2.050, 95%CI: 1.108-3.793), and treatment interval (HR = 1.013\/week, 95%CI: 1.008-1.018). The retreatment HBsAg clearance prediction score (RHCP-S) demonstrated area under the curve of 0.920 (95%CI: 0.863-0.946), sensitivity of 92.3%, specificity of 79.3%. Clearance rates differed significantly: RHCP-S challenge group (\u2264 74 points): 3.45%, RHCP-S probable group (74-110 points): 29.63%, RHCP-S dominant group (\u2265 110 points): 80.95% (P < 0.001).<\/jats:p>\n CONCLUSION<\/jats:p>\n The overall HBsAg clearance rate with Peg-IFN\u03b1-2b retreatment was 20.74% (28\/135). The RHCP-S model identifies optimal retreatment candidates (\u2265 110 points) with 80.95% clearance probability, associated with the absence of combination NA therapy during initial treatment, greater initial HBsAg decline, longer intervals, and lower retreatment HBsAg.<\/jats:p>","DOI":"10.3748\/wjg.v31.i44.112719","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T09:20:43Z","timestamp":1764235243000},"source":"Crossref","is-referenced-by-count":2,"title":["Retreatment hepatitis B surface antigen clearance prediction model identifies pegylated interferon alpha candidates in chronic hepatitis B"],"prefix":"10.3748","volume":"31","author":[{"given":"Yan-Chao","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ling","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000084"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-021-10223-5"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.05.041"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-024-10764-5"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1403805"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29213"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.05.041"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3967\/bes2021.061"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2021.0112"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn501113-20230324-00127"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn501113-20200722-00409"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(22)00124-8"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2022.00289"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.960589"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1116689"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12010361"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v31\/i44\/112719.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v31\/i44\/112719.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T09:21:00Z","timestamp":1764235260000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v31\/i44\/112719.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,28]]},"references-count":16,"journal-issue":{"issue":"44"},"alternative-id":["112719"],"URL":"https:\/\/doi.org\/10.3748\/wjg.v31.i44.112719","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,28]]}}}