{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:38:03Z","timestamp":1783420683988,"version":"3.54.6"},"reference-count":29,"publisher":"Baishideng Publishing Group Inc.","issue":"44","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"<jats:p>With the widespread adoption of colonoscopic screening, the detection rate of rectal neuroendocrine tumors (rNETs) has risen year by year. Treatment strategies for small (&lt; 1 cm) and large (&gt; 2 cm) lesions are relatively well established, but the optimal management pathway for intermediate-sized (1-2 cm) rNETs remains controversial. Inspired by the recent study by Kim et al , this editorial summarizes differences among international guidelines for managing intermediate-sized rNETs, the selection and latest advances in endoscopic techniques, and examines the feasibility and oncologic safety of endoscopic resection for intermediate-sized rNETs. We contend that future management should focus on the clinical application of molecular stratification, biomarkers, and dynamic risk modeling to enable individualized decision-making. Given global disparities in medical resources, a tiered care system based on risk stratification and resource availability should be established to ensure the safety, equity, and accessibility of rNETs treatment.<\/jats:p>","DOI":"10.3748\/wjg.v31.i44.114263","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T09:20:43Z","timestamp":1764235243000},"source":"Crossref","is-referenced-by-count":2,"title":["Redefining therapeutic thresholds and global guidelines: Toward precision management of intermediate-sized rectal neuroendocrine tumors"],"prefix":"10.3748","volume":"31","author":[{"given":"Dan","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Xue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2020.02.25"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.21037\/jgo-20-193"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11050771"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0589"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.01529"},{"key":"B6","unstructured":"National Institute for Health and Care Excellence.   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