{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:30:10Z","timestamp":1789623010489,"version":"build-2803163510"},"reference-count":64,"publisher":"Baishideng Publishing Group Inc.","issue":"45","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Succinate, a metabolite produced by both the gut microbiota and the host, has emerged as a key player in chronic inflammation. In patients with Crohn\u2019s disease (CD), increased succinate in the intestinal lumen correlates with both dysbiosis and greater disease activity.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To investigate circulating succinate as a biomarker of CD activity and its associations with gut microbiota, immune, and clinical features.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>This study with the prospective inclusion of patients with CD in remission, active CD, and non-inflammatory bowel disease controls matched by age, sex, and body mass index. Remission was defined as Harvey-Bradshaw index &lt; 6, C-reactive protein &lt; 0.4 mg\/dL, fecal calprotectin &lt; 250 \u03bcg\/g, and endoscopic activity index Simple Endoscopic Score for CD &lt; 6. Faecal microbiota profiling was performed using 16S rRNA gene sequencing, and demographic, clinical, and treatment variables were recorded along with blood samples (C-reactive protein and succinate) and stool samples.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>Succinate levels were significantly elevated in active CD patients compared to inactive patients and non-inflammatory bowel disease controls. These increases were associated with higher Harvey-Bradshaw Index scores, increased expression of the succinate receptor 1 in immune cells, and enrichment of the succinate-producing genus Prevotella  and the pro-inflammatory phylum Proteobacteria. Conversely, succinate levels negatively correlated with Odoribacter , a known succinate consumer. Interestingly, Dialister , a slow succinate consumer, was enriched in both active and inactive CD patients and was associated with impaired circulating succinate clearance and increased disease activity as well as postoperative recurrence in a validation cohort. Functional microbial analyses revealed upregulation of fumarate reductase and succinate transporters, alongside reduced NADH dehydrogenase expression, indicating disrupted succinate metabolism.<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>These findings highlight succinate as a promising biomarker for CD activity and progression, suggesting that targeting succinate metabolism or key microbial taxa may offer novel therapeutic opportunities.<\/jats:p>","DOI":"10.3748\/wjg.v31.i45.112618","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T06:32:41Z","timestamp":1764743561000},"source":"Crossref","is-referenced-by-count":2,"title":["<i>Dialister<\/i>\n                    -driven succinate accumulation is associated with disease activity and postoperative recurrence in Crohn\u2019s disease"],"prefix":"10.3748","volume":"31","author":[{"given":"Albert","family":"Boronat-Toscano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Isabel","family":"Queipo-Ortu\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diandra","family":"Monfort-Ferr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Suau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Va\u00f1\u00f3-Segarra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Valldosera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Cepero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenno","family":"Astiarraga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Clua-Ferr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Plaza-Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Aranega-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Cabrinety","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carme","family":"Abadia de Barbar\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Castellano-Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Molin\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleidis","family":"Caro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugeni","family":"Dom\u00e8nech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Francisco","family":"S\u00e1nchez-Herrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Benaiges-Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Fern\u00e1ndez-Veledo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Vendrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Gin\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauro","family":"Sumoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Many\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Menacho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Serena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,12,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2010.00449.x"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313235"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.073817"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.11.5224-5231.1998"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309333"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041594"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad119"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-325971"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-021-01135-5"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-14934-z"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1278582"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12760"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2249152"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1177\/17562848221136328"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00554"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2259-4"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0306-4"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.06.013"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/nature11986"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-018-0087-3"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0372-7"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjac069"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.04.061"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2281011"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.06035-11"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2012-13-9-r79"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0764-0"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3109\/00365528909091339"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.082909"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90613-6"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-407863-5.00019-8"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-024-01897-8"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2025.2450207"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2007.05.010"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-014-0078-2"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/s41396-018-0068-2"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1172\/JCI33293"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4261-z"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1172\/JCI173214"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9082448"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.009"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab159"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1404441"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00411.2025"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-025-00672-3"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00400-3"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1949096"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2017.4"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000183"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.07.007"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.07.012"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2190300"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.575455"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.736343"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-025-01063-2"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.041"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00277"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-022-01306-y"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1111\/1751-7915.13536"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2014.02.009"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804812105"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01402-06"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3390\/metabo10090372"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2025.102599"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v31\/i45\/112618.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v31\/i45\/112618.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T06:32:51Z","timestamp":1764743571000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v31\/i45\/112618.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,7]]},"references-count":64,"journal-issue":{"issue":"45"},"alternative-id":["112618"],"URL":"https:\/\/doi.org\/10.3748\/wjg.v31.i45.112618","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,7]]}}}