{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:15:04Z","timestamp":1793502904674,"version":"4.5.0"},"reference-count":68,"publisher":"Baishideng Publishing Group Inc.","issue":"46","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Although epidemiological data on non-alcoholic fatty liver disease in China are available, data on cardiometabolic risk factors have not been addressed under the metabolic dysfunction-associated steatotic liver disease (MASLD) consensus.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To synthesize the epidemiological characteristics of MASLD\/metabolic dysfunction-associated steatohepatitis (MASH), especially their associated cardiometabolic risk factors in China.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>We searched EMBASE, MEDLINE, Central Cochrane, CNKI, and Wangfan for studies from January 1, 2013 to December 31, 2023. Studies involving individuals with MASLD\/MASH in China that reported epidemiological outcomes were included. Meta-analysis was performed to assess the prevalence of MASLD\/MASH. Exploratory outcomes included extrahepatic comorbidities and genetic variants related to MASLD.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>In total, 561 studies involving 6632718 participants were included in this analysis. The prevalence of MASLD and MASH and the annual incidence of MASLD were 30.4% [95% confidence interval (CI): 29.4-31.3], 6.7% (95%CI: 2.2-13.4), and 37 cases per 1000 person-years (95%CI: 28-47), respectively. In addition, the prevalence rates of MASLD in individuals with dyslipidemia, obesity, and hypertension were 59.9% (95%CI: 52.6-67.0), 53.9% (95%CI: 47.9-59.9), and 44.3% (95%CI: 41.1-47.6), respectively. The prevalence of lean MASLD (body mass index &lt; 24 kg\/m2) was 12.0% (95%CI: 10.0-14.0), and 21.7% of the total MASLD population in China had lean MASLD.<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>This study provides a comprehensive overview of the epidemiology and disease burden of MASLD\/MASH in China, providing additional evidence for optimizing MASLD\/MASH management in China and a reference for the global understanding of MASLD\/MASH epidemiology.<\/jats:p>","DOI":"10.3748\/wjg.v31.i46.113608","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T01:35:41Z","timestamp":1765330541000},"source":"Crossref","is-referenced-by-count":11,"title":["Epidemiology of metabolic dysfunction-associated steatotic liver disease\/metabolic dysfunction-associated steatohepatitis and associated cardiometabolic factors in adults in China (2013-2023): A systematic review and meta-analysis"],"prefix":"10.3748","volume":"31","author":[{"given":"Shang-Yu","family":"Chai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru-Ya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Man","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,12,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i47.8263"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002480"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00381-6"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2020.00072"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2020.100099"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000484"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001409"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28785"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.11.007"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000520"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-020-01709-7"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3920196"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.109"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-008204"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30702"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.05.036"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-021-10286-4"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-024-02220-4"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15930"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/apt.18331"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000747"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11020073"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16608"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.67080"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0302155"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4428-y"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.07.021"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.2190\/D4LG-ALJQ-8850-GYDV"},{"key":"B31","doi-asserted-by":"crossref","unstructured":"Warren RC. Ethics and Well-Being: Ages 45-64: 70 is the New 50. J Healthc Sci Humanit 2019; 38-50","DOI":"10.1097\/01.NUMA.0000557621.42684.c4"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2006.01375.x"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.333.7564.362"},{"key":"B34","unstructured":"Zhou BF; Cooperative Meta-Analysis Group of the Working Group on Obesity in China. Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Biomed Environ Sci 2002; 83-96"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.23736\/S2724-6507.20.03273-3"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1199429"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-33753-4"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-022-01234-w"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1001-5256.2023.03.011"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i15.1792"},{"key":"B41","unstructured":"Adila A, Cai W, Yao H, Ma Q. [Association of MTHFR gene polymorphisms and non-alcoholic fatty liver among ethnic Uyghurs]. Xinjiang Yike Daxue Xuebao 2017; 376-379"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13521"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1009-9158.2016.01.011"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1001-9448.2014.13.052"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000004"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30039-1"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-019-00960-3"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2023.11.005"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i4.638"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000471"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32047"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9101346"},{"key":"B53","unstructured":"Vos B, Moreno C, Nagy N, F\u00e9ry F, Cnop M, Vereerstraeten P, Devi\u00e8re J, Adler M. Lean non-alcoholic fatty liver disease (Lean-NAFLD): a major cause of cryptogenic liver disease. Acta Gastroenterol Belg 2011; 389-394"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.20517\/mtod.2024.143"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-024-10662-w"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2020.00082"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30848"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.09.018"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1186\/s40885-020-00146-y"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13602"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1353\/hpu.2011.0166"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0234326"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.14797\/mdcvj.1528"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10110912"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137007"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00275-3"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.2174\/1871530320999201126202706"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.10.040"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v31\/i46\/113608.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v31\/i46\/113608.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T01:36:09Z","timestamp":1765330569000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v31\/i46\/113608.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,14]]},"references-count":68,"journal-issue":{"issue":"46"},"alternative-id":["113608"],"URL":"https:\/\/doi.org\/10.3748\/wjg.v31.i46.113608","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,14]]}}}