{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:02:05Z","timestamp":1791061325546,"version":"4.1.0"},"reference-count":39,"publisher":"Baishideng Publishing Group Inc.","issue":"47","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Helicobacter pylori  (H. pylori ) infection is highly prevalent worldwide, and rising antibiotic resistance has reduced the efficacy of standard therapy, underscoring the need for simplified and better-tolerated regimens.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To evaluate the efficacy, safety, and optimal dosing of vonoprazan (VPZ)-amoxicillin (AMO) dual therapy in a non-inferiority randomized trial for H. pylori  eradication.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>In this multi-center, randomized trial conducted at 17 hospitals in Sichuan Province, China, 1717 adults with confirmed infection were assigned (1:1:1) to 14-day regimens: (1) VPZ 20 mg BID + AMO 0.5 g QID; (2) 0.75 g QID; or (3) 1.0 g TID. The primary endpoint was the eradication rate based on intention-to-treat (ITT) and per-protocol (PP) analyses; secondary endpoints included adverse events (AEs) and treatment compliance.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>Eradication rates were consistently high (92.35%-97.43%). In the 0.5 g QID group, ITT and PP eradication rates were 93.3% (95%CI: 91.2-95.1) and 97.4% (95%CI: 95.7-98.5), respectively, with no significant differences among groups (P  &gt; 0.05). Compliance ranged from 98.1% to 98.3%, and AEs were infrequent (5.2%-7.5%), predominantly mild gastrointestinal symptoms, which occurred least often in the 0.5 g QID group.<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>VPZ-AMO dual therapy achieved excellent eradication, safety, and patient compliance. All regimens were similarly effective, whereas the 0.5 g QID dosing strategy offered the most favorable balance of efficacy and tolerability, supporting its use as a first-line option in high-prevalence settings.<\/jats:p>","DOI":"10.3748\/wjg.v31.i47.114377","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T01:48:29Z","timestamp":1766108909000},"source":"Crossref","is-referenced-by-count":6,"title":["Regional multi-center randomized trial of three vonoprazan-amoxicillin dosing regimens for\n                    <i>Helicobacter pylori<\/i>\n                    eradication in Sichuan Province, 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