{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:20:35Z","timestamp":1792707635281,"version":"4.5.0"},"reference-count":20,"publisher":"Baishideng Publishing Group Inc.","issue":"48","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"<jats:p>Li et al \u2019s recent work on the risk factors for autoimmune gastritis provides clinical context for the vast majority of gastric neuroendocrine tumors (G-NETs). However, a deeper understanding of the underlying pathology is needed for precise clinical management. Our letter details the predictable stepwise progression of type 1 G-NETs from autoimmune-driven corporal atrophy and hypergastrinemia to a clear microscopic sequence of enterochromaffin-like cell precursor lesions, including linear hyperplasia, micronodular hyperplasia, and dysplasia. We highlight the definitive diagnostic thresholds that separate these precursors from overt neoplasia: The 0.5 mm size rule and the presence of submucosal invasion. We advocate for a \u201cprognostic biopsy protocol\u201d in which pathologists actively report these precursor lesions and use Ki-67 to grade G-NETs, providing a quantitative risk assessment. This pathology-centric approach transforms surveillance, allowing clinicians to act on objective microscopic milestones rather than waiting for macroscopically visible tumors.<\/jats:p>","DOI":"10.3748\/wjg.v31.i48.115244","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T10:29:53Z","timestamp":1766744993000},"source":"Crossref","is-referenced-by-count":2,"title":["Unmasking the high-risk phenotype in autoimmune gastritis: A pathologist\u2019s roadmap for the clinician"],"prefix":"10.3748","volume":"31","author":[{"given":"Cheng-Long","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,12,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v31.i41.111449"},{"key":"B2","unstructured":"Kyrlagkitsis I, Karamanolis DG. 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