{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:14:04Z","timestamp":1775805244983,"version":"3.50.1"},"reference-count":10,"publisher":"Baishideng Publishing Group Inc.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"<jats:p>Cholelithiasis has a complex pathogenesis, necessitating better therapeutic and preventive strategies. We recently read with interest Wang et al \u2019s study on lysine acetyltransferase 2A (KAT2A)-mediated adenosine monophosphate-activated protein kinase (AMPK) succinylation in cholelithiasis. Using mouse models and gallbladder mucosal epithelial cells, they found that KAT2A inhibits gallstones through AMPK K170 succinylation, thereby activating the AMPK\/silent information regulator 1 pathway to reduce inflammation and pyroptosis. This study is the first to connect lysine succinylation with cholelithiasis, offering new insights and identifying succinylation as a potential therapeutic target. Future research should confirm these findings using patient samples, investigate other post-translational modifications, and use structural biology to clarify succinylation-induced conformational changes, thereby bridging basic research to clinical applications.<\/jats:p>","DOI":"10.3748\/wjg.v32.i1.114865","type":"journal-article","created":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T07:36:29Z","timestamp":1767512189000},"source":"Crossref","is-referenced-by-count":1,"title":["Potential of lysine succinylation as a therapeutic target for gallstone formation: An insightful strategy"],"prefix":"10.3748","volume":"32","author":[{"given":"Sheng","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang-Rong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v31.i39.110115"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113376"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10255"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-020-01195-1"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.RA119000592"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.26442\/00403660.2019.02.000105"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.hbpd.2020.12.002"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202406633"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-07372-y"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3390\/nu16213588"}],"container-title":["World Journal of Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v32\/i1\/114865.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v32\/i1\/114865.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T07:37:18Z","timestamp":1767512238000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1007-9327\/full\/v32\/i1\/114865.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,7]]},"references-count":10,"journal-issue":{"issue":"1"},"alternative-id":["114865"],"URL":"https:\/\/doi.org\/10.3748\/wjg.v32.i1.114865","relation":{},"ISSN":["1007-9327"],"issn-type":[{"value":"1007-9327","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,7]]}}}