{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:09:09Z","timestamp":1788390549077,"version":"build-2803163510"},"reference-count":44,"publisher":"Baishideng Publishing Group Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Over recent decades, treatment for human immunodeficiency virus (HIV)\/hepatitis C virus (HCV) co-infection has significantly advanced. HIV is known to accelerate liver disease progression and increase liver-related mortality in patients with HCV infection.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To reassess the effectiveness of HCV treatments by comparing outcomes between HIV\/HCV co-infected and HCV mono-infected patients.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>We retrospectively included patients with HCV mono-infection or HIV\/HCV co-infection at 12 tertiary referral centers from January 2009 to December 2020. The primary endpoint was overall survival (OS). Secondary endpoints included achievement of a sustained virologic response (SVR), time-to-occurrence of hepatocellular carcinoma (HCC), and the changes in fibrosis-4 (FIB-4) index.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>A total of 904 patients were included: 792 with HCV mono-infection and 112 with HIV\/HCV co-infection, of whom 97 (86.6%) had received prior HIV treatment. HCV treatment was administered to 741 (93.6%) mono-infected and 86 (76.8%) co-infected patients. Among treated patients, SVR was achieved in 93.4% of mono-infected and 81.4% of the co-infected group [P  = 0.114 after inverse probability of treatment weighting (IPTW) adjustment]. OS and HCC occurrence showed no significant differences between groups, regardless of the HCV treatment method, after IPTW [hazard ratio (HR) = 0.37, 95% confidence interval (95%CI): 0.05-3.07, P  = 0.360 for OS; HR = 0.19, 95%CI: 0.02-1.48, P  = 0.113 for HCC occurrence]. The FIB-4 index significantly improved 1 year after achieving SVR with direct-acting antivirals in both groups.<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>With optimal HIV\/HCV treatment regimens, HCC occurrence and mortality risks in co-infected patients have become comparable to those in patients with HCV mono-infection.<\/jats:p>","DOI":"10.3748\/wjg.v32.i3.114176","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:28:27Z","timestamp":1768523307000},"source":"Crossref","is-referenced-by-count":2,"title":["Chrono-optimal treatments for human immunodeficiency virus\/hepatitis C virus co-infection yield comparable survival outcomes with hepatitis C virus mono-infection"],"prefix":"10.3748","volume":"32","author":[{"given":"Jeayeon","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae 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