{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:01:33Z","timestamp":1784808093450,"version":"3.55.0"},"reference-count":27,"publisher":"Baishideng Publishing Group Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Oral sulfate tablets (OSTs) are commonly used in South Korea, but the requirement to ingest 28 tablets and concerns regarding renal and gastrointestinal safety may reduce patient compliance. DWJ1609 is a novel OST formulation that contains sodium picosulfate and 25% less sulfate, requiring only 20 tablets. This modification is expected to improve tolerability while maintaining cleansing efficacy.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To evaluate the bowel cleansing efficacy and safety of DWJ1609 compared with conventional OSTs and to assess adverse events.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>This prospective, randomized, single-blinded (investigator), multicenter, phase III clinical trial was conducted at seven university hospitals in South Korea. The primary endpoint was the non-inferiority of DWJ1609 based on the proportion of participants achieving a \u201csuccessful\u201d grade A or B on the Harefield Cleansing Scale, as assessed by independent central readers. Safety was monitored through adverse events and laboratory evaluations.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>Overall, 215 participants were randomized, and 200 were included in the per-protocol analysis (DWJ1609: 99; OST: 101). Successful bowel cleansing was achieved in 96.97% of the DWJ1609 group, which was non-inferior to the OST group (100.00%), with a difference of 3.03%. DWJ1609 showed significantly higher tolerability, with lower incidence of nausea, headache, and dizziness, although vomiting occurred slightly more frequently.<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>DWJ1609 demonstrated non-inferior bowel cleansing efficacy, improved tolerability, and a favorable safety profile compared with conventional. DWJ1609 has the potential to improve compliance and overall quality of colonoscopy.<\/jats:p>","DOI":"10.3748\/wjg.v32.i6.113880","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T06:53:43Z","timestamp":1770015223000},"source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and safety of a novel sodium picosulfate oral tablet in a randomized controlled trial for bowel preparation"],"prefix":"10.3748","volume":"32","author":[{"given":"Su Bum","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Bum","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geom Seog","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Soo","family":"Eun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Hwan","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Hoon","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Jun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Mo","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hoon","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Hee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Kyun","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung A","family":"Heo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Il","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2026,2,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14826"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2006.03.918"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1055\/a-0581-8723"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.4166\/kjg.2024.094"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2013.02.009"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-121337"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-019-05599-2"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13477"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.03.1054"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30187-0"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1309086"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/BF02054117"},{"key":"B13","doi-asserted-by":"crossref","unstructured":"Davis GR, Santa Ana CA, Morawski SG, Fordtran JS. 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