{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:39:48Z","timestamp":1793299188851,"version":"4.5.0"},"reference-count":39,"publisher":"Baishideng Publishing Group Inc.","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Endoscopic treatment is the primary therapy for type I gastric neuroendocrine tumors (G-NETs), but it may not address the underlying pathogenesis, increasing the risk of progression.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To investigate the effectiveness of endoscopic treatment and identify progression risk factors.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>This retrospective study involved 128 patients with type I G-NETs treated between January 2009 and May 2024. The patients were categorized into non-progressive (n  = 87) and progressive (n  = 41) groups. Baseline characteristics, treatment details, and follow-up data were analyzed using univariate and multivariate Cox regression analyses to identify prognostic variables.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>The baseline characteristics analysis showed no significant differences between the groups. The median follow-up time was 25.5 months (14.00-58.50 months). The univariate and multivariate analyses confirmed that endoscopic treatment combined with adjuvant somatostatin analogs (SSAs) was associated with a lower risk of progression (hazard ratio = 0.38, 95% confidence interval: 0.17-0.90, P  = 0.027), whereas a neutrophil-to-lymphocyte ratio (NLR) of \u2265 2 indicated a higher risk (hazard ratio = 2.14, 95% confidence interval: 1.08-4.26, P  = 0.030). Kaplan-Meier analysis confirmed NLR \u2265 2 and adjuvant SSA use as independent prognostic variables.<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>Combining endoscopic treatment with SSAs is effective for managing type I G-NETs. SSAs and NLR were identified as independent prognostic factors, highlighting their potential to reduce recurrence risk and improve outcomes.<\/jats:p>","DOI":"10.3748\/wjg.v32.i8.114268","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T03:45:52Z","timestamp":1770695152000},"source":"Crossref","is-referenced-by-count":3,"title":["Progression after endoscopic treatment for type I gastric neuroendocrine tumors: A single-center retrospective 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