{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:59:29Z","timestamp":1787169569511,"version":"build-2736575974"},"reference-count":49,"publisher":"Baishideng Publishing Group Inc.","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastroenterol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>The prognostic value of programmed death ligand-1 (PD-L1) expression in patients with gastric or gastroesophageal junction cancer (G\/GEJC) at different stages remains unclear. We hypothesized that high PD-L1 expression is associated with poor survival in patients with pathological stage III (pIII) G\/GEJC.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To investigate the relation between PD-L1 expression and survival outcomes in patients with pathological stage II (pII)-pIII G\/GEJC.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>In this retrospective cohort study, we collected the clinicopathological data of 388 consecutive patients with pII\/pIII G\/GEJC who underwent gastrectomy without neoadjuvant therapy at Nanfang Hospital, Southern Medical University. Postoperative tissue samples were collected to evaluate PD-L1 expression. Combined positive score (CPS) \u2265 1 was defined as PD-L1-positive, and CPS \u2265 5 as high PD-L1 expression. Survival outcomes were analyzed using Kaplan-Meier and Cox proportional hazards models.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>In pII G\/GEJC, no significant differences were found in 3-year disease-free survival (DFS; 88.5% vs  87.9%, P  = 0.939) or 3-year overall survival (OS; 92.3% vs  89.9%, P  = 0.621) between PD-L1-positive and PD-L1-negative groups or between high and low PD-L1 expression groups (3-year DFS: 91.8% vs  84.2%, P  = 0.138; 3-year OS: 94.2% vs  88.4%, P  = 0.233). In pIII G\/GEJC, PD-L1-positive patients had poorer 3-year DFS (52.2% vs  67.8%, P  = 0.030) and 3-year OS (65.1% vs  78.2%, P  = 0.007) than PD-L1-negative patients. High PD-L1 expression was associated with significantly inferior 3-year DFS (50.2% vs  64.8%, P  = 0.023) and 3-year OS (64.0% vs  75.1%, P  = 0.036) compared to low PD-L1 expression. Multivariate analysis revealed that high PD-L1 expression was independently associated with shorter DFS (HR = 1.624, P  = 0.027) and OS (HR = 1.653, P  = 0.043) in patients with pIII G\/GEJC. Sensitivity analyses confirmed the robustness of the OS findings.<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>High PD-L1 expression serves as an independent adverse prognostic biomarker in stage III but not stage II G\/GEJC. These findings indicate a stage-dependent prognostic value of PD-L1 expression in G\/GEJC.<\/jats:p>","DOI":"10.3748\/wjg.v32.i8.115333","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T03:45:52Z","timestamp":1770695152000},"source":"Crossref","is-referenced-by-count":2,"title":["High PD-L1 expression as a negative prognostic factor in stage III but not in stage II gastric cancer"],"prefix":"10.3748","volume":"32","author":[{"given":"Hui-Min","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng-Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Ru","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Hua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Yuan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rou","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Feng","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jncc.2024.01.006"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn.441530-20200117-00031"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-021-01224-2"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(24)00156-0"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00297-7"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70473-5"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(24)00676-4"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-023-01419-9"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)00052-2"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.02.005"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-020-0075-x"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00797-2"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.19918"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)02033-0"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00541-7"},{"key":"B17","unstructured":"Hu YF, Yu J, Zhang C, Wang YN, Cheng X, Huang F, Li GX. 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