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To overcome this obstacle, scientists are dedicated to discovering new therapeutic strategies and addressing the issue of resistance. Plant-derived chemicals played essential roles in many documented ancient cultures, such as those in ancient China, ancient Egypt, ancient India, and ancient Babylon. Many modern medications are derived from plants, including paclitaxel, a widely used and effective chemotherapy agent originally derived from the Pacific yew tree. Although the development of plant-based compounds for cancer treatment is still under development, these compounds offer several advantages, including a long history of safe use, fewer side effects, lower costs, and improved patient acceptance. Recent studies have shown that plant-derived chemicals can significantly inhibit tumor cell proliferation and reversal drug resistance. Clinical trials have demonstrated promising therapeutic effects of these compounds in cancer treatment. This review summarizes recent research on the role of plant-derived compounds in overcoming drug resistance in pancreatic cancer. It provides insights into the mechanisms of drug resistance and highlights the potential of plant-based compounds as alternative therapeutic strategies. Considering the limitations of current therapies and the growing issue of drug resistance, plant-derived compounds offer a promising direction for enhancing treatment outcomes. This review aims to inform future research and promote the development of more effective, safer, and patient-friendly treatment options for pancreatic cancer.<\/jats:p>","DOI":"10.3748\/wjg.v32.i9.115131","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:28:39Z","timestamp":1772162919000},"source":"Crossref","is-referenced-by-count":0,"title":["Research progress of plant-derived chemical compounds for overcoming pancreatic cancer drug resistance"],"prefix":"10.3748","volume":"32","author":[{"given":"Jia-Qi","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shen-Jie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Hui","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Zhe","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Fang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling-Yu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Fang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao-Feng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Kun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Rong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Song","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Guang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2026,3,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0155"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00457-x"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21442"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.02.012"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000001054"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071412"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011923"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-018-0598-5"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2017.1365598"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000193"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1809775"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.62.8719"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.01895"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5394.2000.86004.x"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.3.491"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2014.07.011"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-023-02814-x"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdj941"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i26.8482"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.09.067"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt347"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm576"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10482"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-018-0004-2"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-2736"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0b013e3282ff0f48"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-18-0899"},{"key":"B28","doi-asserted-by":"crossref","unstructured":"Funamizu N, Okamoto A, Kamata Y, Misawa T, Uwagawa T, Gocho T, Yanaga K, Manome Y. 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