{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:24:41Z","timestamp":1793409881286,"version":"4.5.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mem Cogn"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Semantic dementia (SD) is characterized by progressive impairment in conceptual knowledge due to anterior temporal lobe (ATL) neurodegeneration. Extended neuropsychological assessments can quantitatively demonstrate the semantic impairment, but this graded loss of knowledge can also be readily observed in the qualitative observation of patients\u2019 recall of single concepts. Here, we present the results of a simple task of object drawing-from-name, by patients with SD (<jats:italic>N<\/jats:italic> = 19), who have isolated atrophy of the ATL bilaterally. Both cross-sectionally and longitudinally, patient drawings demonstrated a pattern of degradation in which rare and distinctive features (such as the hump on a camel) were lost earliest in disease course, and there was an increase in the intrusion of prototypical features (such as the typical small ears of most mammals on an elephant) with more advanced disease. Crucially, patient drawings showed a continuum of conceptual knowledge loss rather than a binary \u2018present\u2019 or \u2018absent\u2019 state. Overall, we demonstrate that qualitative evaluation of line drawings of animals and objects provides fascinating insights into the transmodal semantic deficit in SD. Our results are consistent with a distributed-plus-hub model of semantic memory. The graded nature of the deficit in semantic performance observed in our subset of longitudinally observed patients suggests that the temporal lobe binds feature-based semantic attributes in its central convergence zone.<\/jats:p>","DOI":"10.3758\/s13421-024-01578-9","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T18:02:24Z","timestamp":1716400944000},"page":"428-437","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Drawing from name in semantic dementia reveals graded object knowledge representations in anterior temporal lobe"],"prefix":"10.3758","volume":"53","author":[{"given":"Tanmay","family":"Anand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karalyn","family":"Patterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7216-8679","authenticated-orcid":false,"given":"James B","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4751-1786","authenticated-orcid":false,"given":"Thomas E","family":"Cope","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"1578_CR1","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1080\/13554790903405693","volume":"16","author":"A-LR Adlam","year":"2010","unstructured":"Adlam, A.-L.R., Patterson, K., Bozeat, S., & Hodges, J. R. (2010). The Cambridge Semantic Memory Test Battery: Detection of semantic deficits in semantic dementia and Alzheimer\u2019s disease. Neurocase, 16, 193\u2013207. https:\/\/doi.org\/10.1080\/13554790903405693","journal-title":"Neurocase"},{"issue":"10004","key":"1578_CR2","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1016\/S0140-6736(15)00461-4","volume":"386","author":"J Bang","year":"2015","unstructured":"Bang, J., Spina, S., & Miller, B. L. (2015). Frontotemporal dementia. The Lancet: Non-Alzheimer\u2019s. Dementia, 386(10004), 1672\u20131682. https:\/\/doi.org\/10.1016\/S0140-6736(15)00461-4","journal-title":"Dementia"},{"issue":"1","key":"1578_CR3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1080\/02643290244000176","volume":"20","author":"S Bozeat","year":"2003","unstructured":"Bozeat, S., Lambon Ralph, M. A., Graham, K. S., Patterson, K., Wilkin, H., Rowland, J., Rogers, T. T., & Hodges, J. R. (2003). 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Neurobiology of Aging, 30(1), 103\u2013111. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2007.05.014","journal-title":"Neurobiology of Aging"},{"key":"1578_CR5","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.cortex.2019.12.025","volume":"126","author":"TE Cope","year":"2020","unstructured":"Cope, T. E., Shtyrov, Y., MacGregor, L. J., Holland, R., Pulverm\u00fcller, F., Rowe, J. B., & Patterson, K. (2020). Anterior temporal lobe is necessary for efficient lateralised processing of spoken word identity. Cortex, 126, 107\u2013118. https:\/\/doi.org\/10.1016\/j.cortex.2019.12.025","journal-title":"Cortex"},{"key":"1578_CR6","doi-asserted-by":"publisher","unstructured":"Cope, T. E., Sohoglu, E., Peterson, K. A., Jones, P. S., Rua, C., Passamonti, L., Sedley, W., Post, B., Coebergh, J., Butler, C. R., Garrard, P., Abdel-Aziz, K., Husain, M., Griffiths, T. D., Patterson, K., Davis, M. H., & Rowe, J. B. (2023). 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