{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T09:27:44Z","timestamp":1793870864339,"version":"4.6.1"},"reference-count":0,"publisher":"Saudi Heart Association","issue":"1","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the Saudi Heart Association"],"abstract":"<jats:p>Background\nSickle Cell Disease (SCD) is not a hematologic disease that occurs in isolation; it results in multi-organ complications. There is growing evidence of vascular stiffness as its underlying cause.\nThis study aimed to investigate the relationship between endothelial stiffness and LV dysfunction in SCD patients and to explore its pathophysiology, particularly regarding the depletion of vasodilators such as Nitric Oxide (NO).\nMethodology\n32 patients with established criteria for SCD and 40 healthy control subjects were selected for this case-control study. Comprehensive clinical assessment and assessment of endothelial function using Brachial Flow-mediated dilation (FMD) were performed, along with serum NO measurement, which was followed by diagnosis and echocardiographic assessment using 3D speckle tracking echocardiography (STE) and tissue Doppler imaging (TDI).\nResults\nCollected SCD cases showed echocardiographic features of Systo-diastolic dysfunction with reduced FMD compared to controls, denoting endothelial dysfunction in those patients.\nLDH showed a marked elevation, while serum NO showed a significant reduction in cases compared with controls. We also noted a positive correlation between FMD on the one hand and measures of ventricular dysfunction and level of serum NO on the other hand, the latter proving that reduction of NO is responsible for reduced endothelial function.\nConclusion\nWe present the first report to date to outline the role of vascular stiffness as measured by brachial FMD in the induction of left ventricular dysfunction in SCD. We recommend that more research be conducted regarding possible strategies to replenish serum NO stores to delay microvascular injury and, in turn, ventricular dysfunction in SCD.<\/jats:p>","DOI":"10.37616\/2212-5043.1369","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T22:00:56Z","timestamp":1716415256000},"source":"Crossref","is-referenced-by-count":0,"title":["Endothelial dysfunction linked to ventricular dysfunction in children with sickle cell disease, a 3D speckle tracking study."],"prefix":"10.37616","volume":"36","author":[{"given":"Antoine","family":"AbdelMassih","sequence":"first","affiliation":[{"name":"Pediatric Cardiology unit, Department of Pediatrics, Kasr Al Ainy School of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervat","family":"Haroun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kasr Al Ainy School of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha AbdelRaouf","family":"AbdelAziz Afifi","sequence":"additional","affiliation":[{"name":"Pediatric Hematology unit, Department of Pediatrics, Kasr Al Ainy School of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gehan","family":"Hussein","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology unit, Department of Pediatrics, Kasr Al Ainy School of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal","family":"AbdelHameed","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology unit, Department of Pediatrics, Kasr Al Ainy School of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina George","family":"Asaad","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kasr Al Ainy School of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba","family":"Tarabeh","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology unit, Department of Pediatrics, Kasr Al Ainy School of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nourhan Essam","family":"El Din Taha","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kasr Al Ainy School of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nourine","family":"Diab","sequence":"additional","affiliation":[{"name":"Residency program, Faculty of Medicine, New Giza University, New Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noura","family":"Shebl","sequence":"additional","affiliation":[{"name":"Residency program, Faculty of Medicine, New Giza University, New Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghda","family":"Fouda","sequence":"additional","affiliation":[{"name":"Hematology, Faculty of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne Edward","family":"Yassa","sequence":"additional","affiliation":[{"name":"Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Ghobashy","sequence":"additional","affiliation":[{"name":"Radiology department, Faculty of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala","family":"Agha","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology unit, Department of Pediatrics, Kasr Al Ainy School of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24531","published-online":{"date-parts":[[2024,5,21]]},"container-title":["Journal of the Saudi Heart Association"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T08:58:22Z","timestamp":1793869102000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.j-saudi-heart.com\/jsha\/vol36\/iss1\/5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,21]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,5,21]]}},"URL":"https:\/\/doi.org\/10.37616\/2212-5043.1369","relation":{},"ISSN":["2212-5043"],"issn-type":[{"value":"2212-5043","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,21]]}}}