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Nanotechnol."],"accepted":{"date-parts":[[2026,6,10]]},"abstract":"<jats:p>HIV pre-exposure prophylaxis (PrEP) encompasses antiviral drugs or formulations that aim to prevent the establishment of a permanent infection if exposure occurs. Conventional oral PrEP approaches require a daily drug regimen for effective prophylaxis, which can become burdensome, and pill fatigue creates challenges for adherence. There is, consequently, interest in the development of long-acting formulations of antiretrovirals that provide protection over extended periods of time after a single treatment. Nanoformulations and nanoparticle delivery strategies play an important role in achieving long acting (LA)-PrEP. This manuscript reviews emerging nanoparticle delivery platforms for LA-PrEP with a particular focus on four distinct classes of nanomaterials, namely, polymeric nanoparticles, lipid-based nanoparticles, inorganic nanoparticles, and hybrid nanoparticles. 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