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Chem."],"accepted":{"date-parts":[[2015,7,24]]},"abstract":"<jats:p>A convenient approach has been developed to \u03b1-aminoalkylidenebisphosphonates and their asymmetric phosphonyl-phosphinyl and phosphonyl-phosphinoyl analogues by \u03b1-phosphonylation, \u03b1-phosphinylation or \u03b1-phosphinoylation of 1-(<jats:italic>N<\/jats:italic>-acylamino)alkylphosphonates, that, in turn, are easily accessible from <jats:italic>N<\/jats:italic>-acyl-\u03b1-amino acids. Effective electrophilic activation of the \u03b1-position of 1-(<jats:italic>N<\/jats:italic>-acetylamino)alkylphosphonates was achieved by electrochemical \u03b1-methoxylation of these compounds in methanol, mediated with NaCl, followed by displacement of the methoxy group with triphenylphosphonium tetrafluoroborate to give hitherto unknown 1-(<jats:italic>N<\/jats:italic>-acetylamino)-1-triphenylphosphoniumalkylphosphonate tetrafluoroborates. The latter compounds react smoothly with trialkyl phosphites, dialkyl phosphonites or alkyl phosphinites in the presence of H\u00fcnig\u2019s base and methyltriphenylphosphonium iodide in a Michaelis\u2013Arbuzov-like reaction to give the expected alkylidenebisphosphonates, 1-phosphinylalkylphosphonates or 1-phosphinoylalkylphosphonates, respectively, in good yields.<\/jats:p>","DOI":"10.3762\/bjoc.11.153","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T12:38:29Z","timestamp":1439469509000},"page":"1418-1424","source":"Crossref","is-referenced-by-count":11,"title":["A new method for the synthesis of \u03b1-aminoalkylidenebisphosphonates and their asymmetric phosphonyl-phosphinyl and phosphonyl-phosphinoyl 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