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Org. Chem."],"accepted":{"date-parts":[[2021,10,7]]},"abstract":"<jats:p>In the presence of a suitable acid or base, \u03b1-hydroxyaldehydes, ketones, and imines can undergo isomerization that features the 1,2-shift of an alkyl or aryl group. In the process, the hydroxy group is converted to a carbonyl and the aldehyde\/ketone or imine is converted to an alcohol or amine. Such \u03b1-ketol\/\u03b1-iminol rearrangements are used in a wide variety of synthetic applications including asymmetric synthesis, tandem reactions, and the total synthesis and biosynthesis of natural products. 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