{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:16:36Z","timestamp":1790957796555,"version":"4.1.0"},"reference-count":44,"publisher":"Beilstein Institut","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 31901619"],"award-info":[{"award-number":["No. 31901619"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Beilstein J. Org. Chem."],"accepted":{"date-parts":[[2022,9,5]]},"abstract":"<jats:p>\n                    The electrochemical preparation of 2-aminothiazoles has been achieved by the reaction of active methylene ketones with thioureas assisted by \u1d05\u029f-alanine using NH\n                    <jats:sub>4<\/jats:sub>\n                    I as a redox mediator. The electrochemical protocol proceeds in an undivided cell equipped with graphite plate electrodes under constant current conditions. Various active methylene ketones, including \u03b2-keto ester, \u03b2-keto amide, \u03b2-keto nitrile, \u03b2-keto sulfone and 1,3-diketones, can be converted to the corresponding 2-aminothiazoles. Mechanistically, the in situ generated \u03b1-iodoketone was proposed to be the key active species.\n                  <\/jats:p>","DOI":"10.3762\/bjoc.18.130","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T09:29:08Z","timestamp":1663234148000},"page":"1249-1255","source":"Crossref","is-referenced-by-count":8,"title":["A one-pot electrochemical synthesis of 2-aminothiazoles from active methylene ketones and thioureas mediated by NH\n                    <sub>4<\/sub>\n                    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