{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:30:13Z","timestamp":1787790613126,"version":"build-2784847793"},"reference-count":24,"publisher":"Beilstein Institut","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Beilstein J. Org. Chem."],"accepted":{"date-parts":[[2024,3,8]]},"abstract":"<jats:p>\n                    The soil bacterial genus\n                    <jats:italic>Variovorax<\/jats:italic>\n                    produce distinct photoreactive siderophores that may play a crucial role in the iron cycle within the rhizosphere. This study focused on exploring the natural products of the soil-isolated\n                    <jats:italic>Variovorax<\/jats:italic>\n                    sp. H002, leading to the isolation of variochelins A\u2013E (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>5<\/jats:bold>\n                    ), a series of lipohexapeptide siderophores. NMR and MS\/MS analyses revealed that these siderophores share a common core structure \u2013 a linear hexapeptide with \u03b2-hydroxyaspartate and hydroxamate functional groups, serving in iron-binding coordination. Three new variochelins C\u2013E (\n                    <jats:bold>3<\/jats:bold>\n                    \u2013\n                    <jats:bold>5<\/jats:bold>\n                    ) were characterized by varied fatty acyl groups at their\n                    <jats:italic>N<\/jats:italic>\n                    -termini; notably,\n                    <jats:bold>4<\/jats:bold>\n                    and\n                    <jats:bold>5<\/jats:bold>\n                    represent the first variochelins with\n                    <jats:italic>N<\/jats:italic>\n                    -terminal unsaturated fatty acyl groups. Furthermore, the variochelin biosynthetic gene cluster was identified through draft genome sequencing and gene knockout experiments. Compounds\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>5<\/jats:bold>\n                    exhibited antimicrobial activities against Gram-negative bacteria, including several soil-isolated plant pathogens.\n                  <\/jats:p>","DOI":"10.3762\/bjoc.20.63","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T09:33:52Z","timestamp":1712050432000},"page":"692-700","source":"Crossref","is-referenced-by-count":9,"title":["New variochelins from soil-isolated\n                    <i>Variovorax<\/i>\n                    sp. H002"],"prefix":"10.3762","volume":"20","author":[{"given":"Jabal Rahmat","family":"Haedar","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02e16g702","id-type":"ROR","asserted-by":"publisher"},{"id":"https:\/\/www.isni.org\/0000000121737691","id-type":"ISNI","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7665-1027","authenticated-orcid":false,"given":"Aya","family":"Yoshimura","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02e16g702","id-type":"ROR","asserted-by":"publisher"},{"id":"https:\/\/www.isni.org\/0000000121737691","id-type":"ISNI","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2917-1797","authenticated-orcid":false,"given":"Toshiyuki","family":"Wakimoto","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02e16g702","id-type":"ROR","asserted-by":"publisher"},{"id":"https:\/\/www.isni.org\/0000000121737691","id-type":"ISNI","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2086","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s0147-6513(03)00062-9"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1021\/cr9002787"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1039\/b906679a"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/35096545"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b00932"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2778-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-012-4585-z"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02700"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0211876"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.602464"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9421"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.7b00943"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90612-9"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/bf02536089"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1438-9312(200001)102:1<23::aid-ejlt23>3.0.co;2-r"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/s0009-3084(99)00133-4"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1021\/ac970289b"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1021\/ac9701795"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4020(82)80205-6"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1903161116"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1021\/ja026768w"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5456.1245"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv688"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab335"}],"container-title":["Beilstein Journal of Organic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.beilstein-journals.org\/bjoc\/articles\/20\/63","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.beilstein-journals.org\/bjoc\/content\/pdf\/1860-5397-20-63.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.beilstein-journals.org\/bjoc\/articles\/20\/63","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T09:33:55Z","timestamp":1712050435000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.beilstein-journals.org\/bjoc\/articles\/20\/63"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,2]]},"references-count":24,"URL":"https:\/\/doi.org\/10.3762\/bjoc.20.63","archive":["Portico"],"relation":{},"ISSN":["1860-5397"],"issn-type":[{"value":"1860-5397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,2]]}}}