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Chem."],"accepted":{"date-parts":[[2025,9,30]]},"abstract":"<jats:p>\n                    Motivated by the in vivo anxiolytic activity of previously described 1,2,3-benzothiadiazine 1,1-dioxides, we aimed at elaborating a synthetic procedure for the preparation of their pyrrole-fused counterparts, 2,9-dihydro[1,2,3]thiadiazino[5,6-\n                    <jats:italic>g<\/jats:italic>\n                    ]indole 1,1-dioxide derivatives. The simple and versatile process led, via Fischer indole cyclization of the corresponding hydrazones, to a wide structural variety of new tri-, tetra- and pentacyclic ring systems. The structural characterization of (\n                    <jats:italic>E<\/jats:italic>\n                    )- and (\n                    <jats:italic>Z<\/jats:italic>\n                    )-hydrazones was supported by 2D NMR techniques, while that of the target compounds by single-crystal X-ray measurements. The hydrazone intermediates and the new title compounds were subjected to a physicochemical and early ADME characterization study, in the framework of which log\n                    <jats:italic>P<\/jats:italic>\n                    , p\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>a<\/jats:sub>\n                    and log\n                    <jats:italic>k<\/jats:italic>\n                    values were calculated. Following that, kinetic solubility and in vitro gastrointestinal membrane-specific permeability measurements were carried out to assess the lead-likeness of the compounds. Subsequently, the metabolic stability of the most promising derivatives was also determined using human liver microsomes.\n                  <\/jats:p>","DOI":"10.3762\/bjoc.21.169","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T08:48:56Z","timestamp":1761036536000},"page":"2220-2233","source":"Crossref","is-referenced-by-count":1,"title":["Thiadiazino-indole, thiadiazino-carbazole and benzothiadiazino-carbazole dioxides: synthesis, physicochemical and early ADME characterization of representatives of new tri-, tetra- and pentacyclic ring systems and their 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