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Chem."],"accepted":{"date-parts":[[2026,9,8]]},"abstract":"<jats:p>\n                    This study reports an optimized method for the synthesis of spiro-1,2-dihydropyridines via the cycloisomerization of 3-aza-1,5-enynes, catalyzed by heterogeneous gold(I)\u2013polyoxometalate (POM) hybrids. By replacing traditional homogeneous catalysts with these hybrid systems, we achieved high yields (up to 82% isolated) in short reaction times, while minimizing product degradation. The reaction scope was demonstrated across a broad range of substrates, including aryl, alkyl, and heterocyclic derivatives, as well as variations in ring size and nitrogen substituents using 5 mol % of [Au\n                    <jats:sup>I<\/jats:sup>\n                    (IPr)(MeCN)][H\n                    <jats:sub>5<\/jats:sub>\n                    P\n                    <jats:sub>2<\/jats:sub>\n                    W\n                    <jats:sub>18<\/jats:sub>\n                    O\n                    <jats:sub>64<\/jats:sub>\n                    ] as catalyst.\n                  <\/jats:p>","DOI":"10.3762\/bjoc.22.106","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:22:46Z","timestamp":1790594566000},"page":"1316-1322","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of spiro-1,2-dihydropyridine derivatives via cycloisomerization of 3-aza-1,5-enynes catalyzed by gold(I) complex\/polyoxometalate 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