{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:26:13Z","timestamp":1785403573621,"version":"3.56.0"},"reference-count":10,"publisher":"Beilstein Institut","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Beilstein J. Org. Chem."],"accepted":{"date-parts":[[2026,1,12]]},"abstract":"\n In the course of screening vancomycin-resistant enterococci (VRE), two new meroterpenoids, streptoquinolines A (\n 1<\/jats:bold>\n ) and B (\n 2<\/jats:bold>\n ), were isolated from a culture of terrestrial\n Streptomyces<\/jats:italic>\n sp. TMPU-A0679. The structures of\n 1<\/jats:bold>\n and\n 2<\/jats:bold>\n were elucidated based on spectroscopic analyses, including NMR and MS, and were found to consist of a drimane-type sesquiterpene fused with a highly substituted quinoline moiety. Further structural comparisons and specific rotation data revealed that\n 1<\/jats:bold>\n and\n 2<\/jats:bold>\n were epimers at C-4'. Compounds\n 1<\/jats:bold>\n and\n 2<\/jats:bold>\n both exhibited selective antibacterial activity against Gram-positive bacteria, including VRE and methicillin-resistant\n Staphylococcus aureus<\/jats:italic>\n , with minimum inhibitory concentrations ranging from 6.25 to 12.5 \u00b5g\/mL. These results expand the structural and biological diversities of drimane\u2013quinoline-type meroterpenoids and highlight their potential as lead compounds for the development of new antibacterial agents targeting drug-resistant Gram-positive pathogens.\n <\/jats:p>","DOI":"10.3762\/bjoc.22.12","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T10:38:47Z","timestamp":1769510327000},"page":"185-191","source":"Crossref","is-referenced-by-count":0,"title":["Streptoquinolines A and B, new antibacterial meroterpenoids produced by\n Streptomyces<\/i>\n sp. TMPU-A0679"],"prefix":"10.3762","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4845-6791","authenticated-orcid":false,"given":"Akiho","family":"Yagi","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0264zxa45","id-type":"ROR","asserted-by":"publisher"},{"id":"https:\/\/www.isni.org\/0000000121667427","id-type":"ISNI","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitomi","family":"Tomura","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0264zxa45","id-type":"ROR","asserted-by":"publisher"},{"id":"https:\/\/www.isni.org\/0000000121667427","id-type":"ISNI","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami","family":"Konno","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0264zxa45","id-type":"ROR","asserted-by":"publisher"},{"id":"https:\/\/www.isni.org\/0000000121667427","id-type":"ISNI","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuji","family":"Uchida","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0264zxa45","id-type":"ROR","asserted-by":"publisher"},{"id":"https:\/\/www.isni.org\/0000000121667427","id-type":"ISNI","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2086","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(24)01867-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2147\/idr.s54125"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2761"},{"key":"ref4","volume-title":"WHO Bacterial Priority Pathogens List, 2024: bacterial pathogens of public health importance to guide research, development and strategies to prevent and control antimicrobial resistance","year":"2024"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/s41429-024-00805-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41429-025-00838-3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1126\/science.1105486"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/md17020098"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1021\/jo501720b"},{"key":"ref10","volume-title":"Reference methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, approved standard CLSI document M07-A11","year":"2019","edition":"11"}],"container-title":["Beilstein Journal of Organic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.beilstein-journals.org\/bjoc\/articles\/22\/12","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.beilstein-journals.org\/bjoc\/content\/pdf\/1860-5397-22-12.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.beilstein-journals.org\/bjoc\/articles\/22\/12","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T10:38:48Z","timestamp":1769510328000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.beilstein-journals.org\/bjoc\/articles\/22\/12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,27]]},"references-count":10,"URL":"https:\/\/doi.org\/10.3762\/bjoc.22.12","archive":["Portico"],"relation":{},"ISSN":["1860-5397"],"issn-type":[{"value":"1860-5397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,27]]}}}