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Org. Chem."],"accepted":{"date-parts":[[2026,4,23]]},"abstract":"<jats:p>\n                    A sustainable photocatalytic protocol for the trifluoromethylation of (hetero)arenes is reported. The method operates under metal- and base-free conditions using an inexpensive and atom-efficient CF\n                    <jats:sub>3<\/jats:sub>\n                    source, trifluoroacetic anhydride, in ethyl acetate as a green solvent. An organic cyanoarene photocatalyst enables efficient CF\n                    <jats:sub>3<\/jats:sub>\n                    radical generation under blue-light irradiation, providing a broad range of trifluoromethylated arenes and heteroarenes. The reaction displays pronounced sensitivity to substituent patterns rather than electronic effects. Mechanistic investigations, including radical trapping, Stern\u2013Volmer analysis, and DFT calculations, support a reductive quenching pathway involving photocatalyst-mediated reduction of TFAA. The protocol is amenable to scale-up, with continuous-flow operation delivering a significant increase in space\u2013time yield, highlighting its potential for sustainable synthesis of CF\n                    <jats:sub>3<\/jats:sub>\n                    -containing molecules.\n                  <\/jats:p>","DOI":"10.3762\/bjoc.22.50","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:01:38Z","timestamp":1777536098000},"page":"662-671","source":"Crossref","is-referenced-by-count":1,"title":["Photoorganocatalytic trifluoromethylation of (het)arenes in green conditions"],"prefix":"10.3762","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9785-426X","authenticated-orcid":false,"given":"Egor 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