{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:41:25Z","timestamp":1785436885862,"version":"3.56.0"},"reference-count":32,"publisher":"Beilstein Institut","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Beilstein J. Org. Chem."],"accepted":{"date-parts":[[2026,5,7]]},"abstract":"<jats:p>\n                    The first synthesis of 3-(alkylamino)imidazo[1,2-\n                    <jats:italic>a<\/jats:italic>\n                    ]pyridine-2-carbaldehydes is reported. A Groebke\u2013Blackburn\u2013Bienaym\u00e9 reaction between 2-aminopyridine derivatives, cyclohexyl isocyanide and glyoxylic acid in the presence of methanol and an acid catalyst gave the 2-ester derivatives that were reduced to give the corresponding alcohols. Mild Kornblum oxidation conditions, reaction in the presence of DMSO and NaHCO\n                    <jats:sub>3<\/jats:sub>\n                    under conventional or microwave heating to \u2248100 \u00b0C, were applied to the bromides derived from these alcohols by treatment with PBr\n                    <jats:sub>3<\/jats:sub>\n                    , resulting in the desired aldehydes which successfully underwent reductive amination reactions with 2-chloroaniline. Alternative oxidation conditions such as PCC, IBX or\n                    <jats:italic>T. versicolor<\/jats:italic>\n                    laccase applied to the alcohols led only to oxidative ring-opening to give oxalamide derivatives, with no aldehyde being isolated.\n                  <\/jats:p>","DOI":"10.3762\/bjoc.22.58","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T08:32:26Z","timestamp":1779179546000},"page":"763-770","source":"Crossref","is-referenced-by-count":0,"title":["Preparation of 3-(alkylamino)imidazo[1,2-\n                    <i>a<\/i>\n                    ]pyridine-2-carbaldehydes via Kornblum oxidation and unexpected ring-opening reactions of the corresponding alcohols under oxidative conditions"],"prefix":"10.3762","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6481-7413","authenticated-orcid":false,"given":"Sandile 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