{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:27:47Z","timestamp":1785432467262,"version":"3.56.0"},"reference-count":40,"publisher":"Beilstein Institut","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["grants LE0668477, LE140100119, LE0237908 and LE230100128"],"award-info":[{"award-number":["grants LE0668477, LE140100119, LE0237908 and LE230100128"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Beilstein J. Org. Chem."],"accepted":{"date-parts":[[2026,6,17]]},"abstract":"<jats:p>\n                    The known lichen depside, lecanoric acid (\n                    <jats:bold>1<\/jats:bold>\n                    ), was identified as a scaffold of interest for the generation of a unique semisynthetic biodiscovery screening library. Large-scale extraction and isolation on the Australian-sourced lichen\n                    <jats:italic>Parmotrema tinctorum<\/jats:italic>\n                    resulted in the purification of \u22481 g of the desired scaffold\n                    <jats:bold>1<\/jats:bold>\n                    , along with other known lichen metabolites that included divaricatic acid (\n                    <jats:bold>2<\/jats:bold>\n                    ), orcinol (\n                    <jats:bold>3<\/jats:bold>\n                    ), orsellinic acid (\n                    <jats:bold>4<\/jats:bold>\n                    ), and methyl orsellinate (\n                    <jats:bold>5<\/jats:bold>\n                    ). Parallel solution-phase synthesis using amidation chemistry on the abundant scaffold\n                    <jats:bold>1<\/jats:bold>\n                    afforded a series of novel amide derivatives\n                    <jats:bold>6<\/jats:bold>\n                    \u2013\n                    <jats:bold>13<\/jats:bold>\n                    in high purity (&gt;95%) and low to moderate yields (12\u201353%). All new semisynthetic compounds were fully characterised following 1D\/2D NMR, MS and UV data analysis. Crystalline lecanoric acid was obtained during the chemical investigations of the lichen extract, enabling the first X-ray crystallographic analysis to be undertaken on this depside. Compounds\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>13<\/jats:bold>\n                    were evaluated for antibacterial activity against the human pathogen\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    using a biofilm inhibition assay. Of the new semisynthetics, amide analogue\n                    <jats:bold>12<\/jats:bold>\n                    showed the greatest planktonic cell growth inhibition (13% at 50 \u00b5M), whilst amide analogue\n                    <jats:bold>11<\/jats:bold>\n                    was the most active at inhibiting the formation of biofilm (21% at 50 \u00b5M).\n                  <\/jats:p>","DOI":"10.3762\/bjoc.22.81","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T13:01:09Z","timestamp":1782910869000},"page":"1023-1032","source":"Crossref","is-referenced-by-count":0,"title":["Semisynthesis, characterisation, and antibacterial evaluation of a novel lecanoric acid-derived amide library"],"prefix":"10.3762","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5615-3208","authenticated-orcid":false,"given":"Ethan 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