{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:17:36Z","timestamp":1785403056472,"version":"3.56.0"},"reference-count":38,"publisher":"Beilstein Institut","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003968","name":"Iran National Science Foundation","doi-asserted-by":"publisher","award":["project No.4037019"],"award-info":[{"award-number":["project No.4037019"]}],"id":[{"id":"10.13039\/501100003968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Beilstein J. Org. Chem."],"accepted":{"date-parts":[[2026,6,30]]},"abstract":"<jats:p>\n                    Dithiocarbamates are widely recognized for their versatile applications in both agriculture as effective pesticides and medicine, where they serve as antifungal and anticancer agents. As a result, their synthesis has garnered significant attention in recent years. In this study, we present an efficient one-pot four-component approach for the synthesis of these scaffolds, utilizing aldehydes, ethyl acetoacetate, carbon disulfide (CS\n                    <jats:sub>2<\/jats:sub>\n                    ), and amines. Initially, \u03b1,\u03b2-unsaturated carbonyl compounds, serving as Michael acceptors, were generated from aldehydes and ethyl acetoacetate through a decarboxylative Knoevenagel reaction under mild conditions, using lipase as a biocatalyst. These intermediates then sequentially undergo a nucleophilic addition reaction with dithiocarbamate anions, which are generated in situ by reacting CS\n                    <jats:sub>2<\/jats:sub>\n                    with amines. This sequence successfully yields 15 derivatives of\n                    <jats:italic>S<\/jats:italic>\n                    -alkylated dithiocarbamates with high to excellent yields ranging from 69% to 96%.\n                  <\/jats:p>","DOI":"10.3762\/bjoc.22.83","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:37:52Z","timestamp":1783683472000},"page":"1048-1056","source":"Crossref","is-referenced-by-count":0,"title":["One-pot four-component sequential synthesis of\n                    <i>S<\/i>\n                    -alkyl dithiocarbamates using lipase as a biocatalyst"],"prefix":"10.3762","volume":"22","author":[{"given":"Mansour","family":"Shahedi","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0091vmj44","id-type":"ROR","asserted-by":"publisher"},{"id":"https:\/\/www.isni.org\/0000000106864748","id-type":"ISNI","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9982-4854","authenticated-orcid":false,"given":"Pargol","family":"Tahmasebi pour","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0091vmj44","id-type":"ROR","asserted-by":"publisher"},{"id":"https:\/\/www.isni.org\/0000000106864748","id-type":"ISNI","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohreh","family":"Habibi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0091vmj44","id-type":"ROR","asserted-by":"publisher"},{"id":"https:\/\/www.isni.org\/0000000106864748","id-type":"ISNI","asserted-by":"publisher"}]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2086","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1080\/17415993.2025.2497317"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031317"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24152806"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104346"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1021\/jf950751y"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/10426507.2013.797416"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.01.001"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s13738-012-0206-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.02.030"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2147\/dddt.s354879"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.2c00423"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c01652"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e09564"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.8b03685"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202001050"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.5c00174"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.202401011"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2025.155680"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.4c02063"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1039\/d2qo00311b"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2014.04.041"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1021\/jo060048g"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2020.152270"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.3c02722"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1080\/17415993.2020.1778698"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2013.07.124"},{"key":"ref27","first-page":"41","volume":"1","author":"Choudhury","year":"2015","journal-title":"Biopharm J."},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.140486"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3390\/catal12090960"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1002\/btpr.2581"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1002\/slct.201702954"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1002\/ajoc.202300427"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200400213"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1039\/b817524a"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1039\/b914653a"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1039\/d2ob02307e"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcat.2020.110983"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1039\/d3nj03722c"}],"container-title":["Beilstein Journal of Organic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.beilstein-journals.org\/bjoc\/articles\/22\/83","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.beilstein-journals.org\/bjoc\/content\/pdf\/1860-5397-22-83.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.beilstein-journals.org\/bjoc\/articles\/22\/83","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:37:53Z","timestamp":1783683473000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.beilstein-journals.org\/bjoc\/articles\/22\/83"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,10]]},"references-count":38,"URL":"https:\/\/doi.org\/10.3762\/bjoc.22.83","archive":["Portico"],"relation":{},"ISSN":["1860-5397"],"issn-type":[{"value":"1860-5397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,10]]}}}