{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:34:35Z","timestamp":1772253275076,"version":"3.50.1"},"reference-count":26,"publisher":"Beilstein Institut","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2021-123059OB-I00"],"award-info":[{"award-number":["PID2021-123059OB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002704","name":"Fundaci\u00f3n Cient\u00edfica Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer","doi-asserted-by":"publisher","award":["PRDTF233958GONZ"],"award-info":[{"award-number":["PRDTF233958GONZ"]}],"id":[{"id":"10.13039\/501100002704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["2022.02910.PTDC"],"award-info":[{"award-number":["2022.02910.PTDC"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/50006\/2020|UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020|UIDP\/50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Beilstein J. Org. Chem."],"accepted":{"date-parts":[[2024,5,13]]},"abstract":"<jats:p>\n                    Considering early-stage drug discovery programs, the Ugi four-component reaction is a valuable, flexible, and pivotal tool, facilitating the creation of two new amide bonds in a one-pot fashion to effectively yield the desired \u03b1-aminoacylamides. Here, we highlight the reputation of this reaction approach to access number and scaffold diversity of a library of isatin-based \u03b1-acetamide carboxamide oxindole hybrids, promising anticancer agents, in a mild and fast sustainable reaction process. The library was tested against six human solid tumor cell lines, among them, non-small cell lung carcinoma, cervical adenocarcinoma, breast cancer and colon adenocarcinoma. The most potent compounds\n                    <jats:bold>8d<\/jats:bold>\n                    ,\n                    <jats:bold>8h<\/jats:bold>\n                    and\n                    <jats:bold>8k<\/jats:bold>\n                    showed GI\n                    <jats:sub>50<\/jats:sub>\n                    values in the range of 1\u201310 \u03bcM.\n                  <\/jats:p>","DOI":"10.3762\/bjoc.20.104","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T04:55:27Z","timestamp":1716785727000},"page":"1213-1220","source":"Crossref","is-referenced-by-count":8,"title":["The Ugi4CR as effective tool to access promising anticancer isatin-based \u03b1-acetamide carboxamide oxindole hybrids"],"prefix":"10.3762","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1697-7871","authenticated-orcid":false,"given":"Carolina S","family":"Marques","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02gyps716","id-type":"ROR","asserted-by":"publisher"},{"id":"https:\/\/www.isni.org\/0000000093106111","id-type":"ISNI","asserted-by":"publisher"}]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9792-5194","authenticated-orcid":false,"given":"Aday","family":"Gonz\u00e1lez-Bakker","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01r9z8p25","id-type":"ROR","asserted-by":"publisher"},{"id":"https:\/\/www.isni.org\/0000000121060879","id-type":"ISNI","asserted-by":"publisher"}]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6268-6552","authenticated-orcid":false,"given":"Jos\u00e9 M","family":"Padr\u00f3n","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01r9z8p25","id-type":"ROR","asserted-by":"publisher"},{"id":"https:\/\/www.isni.org\/0000000121060879","id-type":"ISNI","asserted-by":"publisher"}]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2086","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118863992"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/ph15081009"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.3c00012"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1039\/d0ra07501a"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b03684"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1083239"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2021.1858797"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111842"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-08-102083-8.00006-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/slct.201600932"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.103753"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1737343"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2023.101032"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1039\/d2md00044j"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1039\/d2nj03627d"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"ref18","first-page":"451","volume":"10","author":"Chhikara","year":"2023","journal-title":"Chemical Biology Letters"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1021\/jm200187y"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.113102"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.1c00344"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/tcr.202000167"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/ajoc.202100684"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2023.1114970"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2019.1614910"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1039\/c5ob01457c"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.201600901"}],"container-title":["Beilstein Journal of Organic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.beilstein-journals.org\/bjoc\/articles\/20\/104","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.beilstein-journals.org\/bjoc\/content\/pdf\/1860-5397-20-104.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.beilstein-journals.org\/bjoc\/articles\/20\/104","content-type":"text\/html","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T04:55:32Z","timestamp":1716785732000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.beilstein-journals.org\/bjoc\/articles\/20\/104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,27]]},"references-count":26,"URL":"https:\/\/doi.org\/10.3762\/bjoc.20.104","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.3762\/bxiv.2023.60.v1","asserted-by":"object"}]},"ISSN":["1860-5397"],"issn-type":[{"value":"1860-5397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,27]]}}}