{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:42:57Z","timestamp":1792798977228,"version":"4.5.0"},"reference-count":4,"publisher":"Westerdijk Fungal Biodiversity Institute","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["persoonia"],"published-print":{"date-parts":[[2013,6,30]]},"abstract":"<jats:p>Mucormycosis usually presents as a progressive infection with significant angio-invasion. Mucormycosis due to <jats:italic>Mucor irregularis<\/jats:italic> (formerly <jats:italic>Rhizomucor variabilis<\/jats:italic> var. <jats:italic>variabilis<\/jats:italic>), however, is exceptional in causing chronic cutaneous infection in immunocompetent humans,\n ultimately leading to severe morbidity if left untreated. More than 90 % of the cases known to date were reported from Asia, mainly from China. The nearest neighbour of <jats:italic>M. irregularis<\/jats:italic> is the saprobic species <jats:italic>M. hiemalis<\/jats:italic>. The aim of this study was to evaluate the taxonomic position,\n epidemiology, and intra- and inter-species diversity of <jats:italic>M. irregularis<\/jats:italic> based on 21 strains (clinical n = 17) by multilocus analysis using ITS, LSU, <jats:italic>RPB1<\/jats:italic> and <jats:italic>RPB2<\/jats:italic> genes, compared to results of cluster analysis with amplified fragment length polymorphism (AFLP) data. By\n combining MLST and AFLP analyses, <jats:italic>M. irregularis<\/jats:italic> was found to be monophyletic with high bootstrap support, and consisted of five subgroups, which were not concordant in all partitions. It was thus confirmed that <jats:italic>M. irregularis<\/jats:italic> is a single species at 96.1\u2013100 % ITS similarity\n and low recombination rates between populations. Some geographic structuring was noted with some localised populations, which may be explained by limited air-dispersal. The natural habitat of the species is likely to be in soil and decomposing plant material.<\/jats:p>","DOI":"10.3767\/003158513x665539","type":"journal-article","created":{"date-parts":[[2013,3,31]],"date-time":"2013-03-31T03:47:02Z","timestamp":1364701622000},"page":"48-56","source":"Crossref","is-referenced-by-count":69,"title":["Taxonomy and epidemiology of <i>Mucor irregularis<\/i> , agent of chronic cutaneous mucormycosis"],"prefix":"10.3114","volume":"30","author":[{"given":"X.-L.","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"Najafzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Dolatabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-P.","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.H.G.","family":"Gerrits van den Ende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-N.","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.-Y.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.-Y.","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.-Q.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.-Y.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.-M.","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.-X.","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-J.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Drogari-Apiranthitou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Klaassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.F.","family":"Meis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Hagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.-D.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.S.","family":"de Hoog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1645","reference":[{"key":"R59_315_658","first-page":"4410","volume":"48","journal-title":"JournalofClinicalMicrobiology","ISSN":"https:\/\/id.crossref.org\/issn\/0004-5632","issn-type":"print"},{"key":"R60_315_256","first-page":"714","volume":"49","journal-title":"MedicalMycology","ISSN":"https:\/\/id.crossref.org\/issn\/1369-3786","issn-type":"print"},{"key":"R60_48_530","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.femsre.2005.01.004","volume":"29","journal-title":"FEMSMicrobiologyReviews","ISSN":"https:\/\/id.crossref.org\/issn\/0168-6445","issn-type":"print"},{"key":"R60_48_244","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0141-0229(99)00173-8","volume":"26","journal-title":"Enzyme and Microbiology Technology","ISSN":"https:\/\/id.crossref.org\/issn\/0141-0229","issn-type":"print"}],"container-title":["Persoonia - Molecular Phylogeny and Evolution of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/wfbi\/pimj\/2013\/00000030\/00000001\/art00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T04:44:26Z","timestamp":1750221866000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.3767\/003158513X665539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,30]]},"references-count":4,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,6,30]]}},"alternative-id":["0031-5850(20130630)30:1L.48;1-"],"URL":"https:\/\/doi.org\/10.3767\/003158513x665539","relation":{},"ISSN":["0031-5850"],"issn-type":[{"value":"0031-5850","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6,30]]}}}