{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T12:24:56Z","timestamp":1793795096299,"version":"4.6.1"},"reference-count":0,"publisher":"China Medical University","issue":"3","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMedicine"],"abstract":"<jats:p>Background: Traumatic brain injury (TBI) is a severe health problem for which there is no specific treatment, leading to neurological or neuropsychological consequences. One of the most described disorders, even after mild TBI (mTBI), is depression, related to mechanisms involving reactive oxygen species (ROS). The Mucuna pruriens (M. pruriens) plant has various antioxidant, neuroprotective, and anti-inflammatory properties.\nPurpose: There is insufficient evidence of M. pruriens use for the treatment of neurobehavioral and depressive impairments induced by TBI and of the mechanisms underlying this effect, so we aimed to evaluate the ability of shortterm administration of M. pruriens extract to prevent neurobehavioral impairment and depression-like behaviors in a murine model of mTBI as well as evaluate the role of oxidative stress.\nMethods: Male Wistar rats underwent mTBI or sham surgery. Immediately after, they were treated with vehicle or M. pruriens extract (50 mg\/kg ip\/day for five days). We evaluated neurobehavioral recovery using the Neurobehavioral Severity\nScale-Revised (NSS-R) and the immobility time in the forced swimming test 3, 7, 15, 30, and 60 days after mTBI. In addition, lipid peroxidation (LP) and GSH concentrations were determined in some brain areas (motor cortex, striatum, midbrain, and nucleus accumbens).\nResults: M. pruriens extract did not decrease neurobehavioral impairment caused by mTBI. Nevertheless, it prevented depression-like behaviors starting three days after mTBI, reduced LP, and increased GSH in some brain areas.\nConclusions: M. pruriens may prevent depression-like behaviors and reduce oxidative stress by decreasing LP and increasing concentrations of antioxidant compounds.\nKey Words: Mucuna pruriens, Depression, Traumatic Brain Injury, Oxidative Stress, Lipid Peroxidation, Reduced Glutathione<\/jats:p>","DOI":"10.37796\/2211-8039.1461","type":"journal-article","created":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T18:16:51Z","timestamp":1725128211000},"source":"Crossref","is-referenced-by-count":6,"title":["Effect of Mucuna pruriens seed extract on depression-like behavior derived  from mild traumatic brain injury in rats"],"prefix":"10.37796","volume":"14","author":[{"given":"Alfonso","family":"Mata-Bermudez","sequence":"first","affiliation":[{"name":"Departamento de Fisiolog\u00eda Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Apdo.Postal 70-250, 04510 Ciudad de M\u00e9xico, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Trejo-Ch\u00e1vez","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Apdo.Postal 70-250, 04510 Ciudad de M\u00e9xico, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Mart\u00ednez-Vargas","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Apdo.Postal 70-250, 04510 Ciudad de M\u00e9xico, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad\u00e1n","family":"P\u00e9rez-Arredondo","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Apdo.Postal 70-250, 04510 Ciudad de M\u00e9xico, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda de los \u00c1ngeles","family":"Mart\u00ednez-C\u00e1rdenas","sequence":"additional","affiliation":[{"name":"Departamento de Atenci\u00f3n a la Salud, Universidad Aut\u00f3noma Metropolitana Unidad Xochimilco, Ciudad de M\u00e9xico, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Araceli","family":"Diaz-Ruiz","sequence":"additional","affiliation":[{"name":"Departamento de Neuroqu\u00edmica, Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda Manuel Velasco Suarez, Ciudad de M\u00e9xico, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilo","family":"Rios","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda Molecular, Departamento de Sistemas Biol\u00f3gicos, Universidad Aut\u00f3noma Metropolitana Unidad Xochimilco, Ciudad de M\u00e9xico, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor Alonso","family":"Romero-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Departamento de Atenci\u00f3n a la Salud, Universidad Aut\u00f3noma Metropolitana Unidad Xochimilco, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustino","family":"Mart\u00ednez-Antonio","sequence":"additional","affiliation":[{"name":"Biological Engineering Laboratory, Genetic Engineering Department, Center for Research and Advanced Studies of the National Polytechnic Institute (Cinvestav), Campus Irapuato, Guanajuato, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz","family":"Navarro","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Apdo.Postal 70-250, 04510 Ciudad de M\u00e9xico, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"12796","published-online":{"date-parts":[[2024,8,30]]},"container-title":["BioMedicine"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T11:25:02Z","timestamp":1793791502000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biomedicinej.com\/biomedicine\/vol14\/iss3\/3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,30]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,8,30]]}},"URL":"https:\/\/doi.org\/10.37796\/2211-8039.1461","relation":{},"ISSN":["2211-8039"],"issn-type":[{"value":"2211-8039","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,30]]}}}