{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T11:31:34Z","timestamp":1793791894214,"version":"4.6.1"},"reference-count":0,"publisher":"China Medical University","issue":"2","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMedicine"],"abstract":"<jats:p>Introduction: Genetic polymorphisms in DNA repair pathways can modulate\nDNA repair capacity and influence susceptibility to aging-related disorders, including Parkinson\u2019s disease (PD). This study evaluated the association between the DNA ligase I rs20579 polymorphism and PD risk.\nMaterials and Methods: Genotyping of DNA ligase I rs20579 was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in\n123 PD patients and 492 age- and sex-matched controls of Taiwanese Han ethnicity.\nAssociations between rs20579 genotypes and PD risk were analyzed. \nResults: Among controls, the genotype distribution of rs20579 was 78.7% GG, 19.3% AG, and 2.0% AA, compared with 75.6%, 21.1%, and 3.3% among PD cases, respectively (p for trend=0.6290). No significant differences were observed in the prevalence of AG (p=0.6939) or AA (p=0.4908) genotypes between cases and controls. Allelic analysis showed a non-significant increase in PD risk for A allele carriers (OR=1.21, 95% CI=0.80\u20131.83, p=0.4189). Stratified analysis revealed no significant genotype differences among males. In females, the AA genotype was associated with a borderline increased risk of PD (OR=1.86, 95% CI=1.00\u20133.47, p=0.0526). \nConclusion: In this Taiwanese Han cohort, the DNA ligase I rs20579 A allele may be a genetic marker of increased PD susceptibility in females. Further studies in larger, independent populations are warranted to confirm its clinical relevance.<\/jats:p>","DOI":"10.37796\/2211-8039.1681","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T16:18:36Z","timestamp":1779898716000},"source":"Crossref","is-referenced-by-count":1,"title":["Impacts of DNA ligase I genotypes on Taiwan Parkinson\u2019s disease"],"prefix":"10.37796","volume":"16","author":[{"given":"Chao-Hsuan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Shin","family":"Chang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Wen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Tian","family":"Bau","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Wei","family":"Hsu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Ting","family":"Hong","sequence":"additional","affiliation":[{"name":"National Defense Medical University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chon-Haw","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuu-Jen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Kuei","family":"Lu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jai-Sing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"12796","published-online":{"date-parts":[[2026,5,26]]},"container-title":["BioMedicine"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T11:23:53Z","timestamp":1793791433000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.biomedicinej.com\/biomedicine\/vol16\/iss2\/2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,5,26]]}},"URL":"https:\/\/doi.org\/10.37796\/2211-8039.1681","relation":{},"ISSN":["2211-8039"],"issn-type":[{"value":"2211-8039","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,26]]}}}